Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men.
Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men.
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中国汉族男性ADIPOQ基因的遗传变异与前列腺癌风险
DOI：
10.4103/1008-682x.129939
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发表时间：
2014-11
影响因子：
2.9
通讯作者：
Ye DW
中科院分区：
文献类型：
--
作者：
Gu CY;Li QX;Zhu Y;Wang MY;Shi TY;Yang YY;Wang JC;Jin L;Wei QY;Ye DW
脂肪组织分泌的脂联素与前列腺癌的发生有关。ADIPOQ的遗传变异被认为影响脂联素的活性，从而与癌症的发生有关。在这项以医院为基础的病例对照研究中，917例前列腺癌（PCa）病例和1036例非癌症对照，我们评估了中国汉族男性ADIPOQ单核苷酸多态性与PCa风险和脂联素水平的相关性。采用Taqman聚合酶链反应方法对ADIPOQ变异体进行基因分型。采用酶联免疫吸附试验（ELISA）测定病例组和对照组的血浆脂联素浓度。我们发现ADIPOQ rs3774262变异AA基因型与PCa风险降低[校正比值比（OR）：0.66，95%置信区间（CI）=0.48-0.92]和血浆脂联素水平升高（P = 0.036和0.043）相关，肿瘤分级、临床分期和侵袭性差异显著。ADIPOQ rs3774262和体重指数之间的显著相互作用可改变PCa的风险（P = 6.7 × 10−3）。ADIPOQ rs 266729和rs 182052与PCa风险或血浆脂联素水平无关。我们的数据支持ADIPOQ rs3774262可能与血浆脂联素水平联合影响中国汉族男性PCa风险。这可能有助于肥胖和前列腺癌之间的关联的分子基础。
Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis. Genetic variations in ADIPOQ are thought to influence the activity of adiponectin, thus relating to cancer occurrence. In this hospital-based case-control study of 917 prostate cancer (PCa) cases and 1036 cancer-free controls, we evaluated the association of single nucleotide polymorphisms in ADIPOQ with risk of PCa and adiponectin levels in Chinese Han men. Variants of ADIPOQ were genotyped by Taqman polymerase chain reaction method. The plasma adiponectin concentrations were measured by enzyme-linked immunosorbent assay (ELISA) in a subset of cases and controls. We found that the ADIPOQ rs3774262 variant AA genotype was associated with both decreased PCa risk [adjusted odds ratio (OR): 0.66, 95% confidence interval (CI) =0.48–0.92] and increased plasma adiponectin levels (P = 0.036 and 0.043), with significant difference by tumor grade, clinical stage, and aggressiveness. A significant interaction between ADIPOQ rs3774262 and body mass index was observed in modifying the risk of PCa (P = 6.7 × 10−3). ADIPOQ rs266729 and rs182052 were not related to PCa risk or plasma adiponectin levels. Our data support that ADIPOQ rs3774262 may affect PCa risk in combination with plasma adiponectin levels in Chinese Han men. It may contribute to the molecular basis for the association between obesity and PCa.