Testing Models for the Contributions of Genes and Environment to Developmental Change in Adolescent Depression
Testing Models for the Contributions of Genes and Environment to Developmental Change in Adolescent Depression
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DOI：
10.1007/s10519-015-9715-9
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发表时间：
2015-07-01
影响因子：
2.6
通讯作者：
Silberg, Judy L.
中科院分区：
文献类型：
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作者：
Gillespie, Nathan A.;Eaves, Lindon J.;Silberg, Judy L.
我们测试了两个模型，以确定青少年抑郁症纵向变化背后的遗传和环境过程。第一种假设认为，观察到的协方差结构的变化是抑郁症总体水平和变化率随时间(随机增长曲线)的内在随机个体差异展开的结果。第二种假设认为观察到的变化是由于特定时间的随机效应(创新)随着时间积累(自回归效应)。我们几乎没有发现年龄相关的遗传效应或持续的基因创新的证据。相反，遗传效应与抑郁症的易感性和随年龄增长的变化率的逐渐展开是一致的。同样，环境也会在总体抑郁水平和变化率方面造成显著的个体差异。然而，也有特定于时间的环境体验，保持着保真度。这些不同的遗传和环境机制在抑郁症的病因学中的含义被考虑。
We tested two models to identify the genetic and environmental processes underlying longitudinal changes in depression among adolescents. The first assumes that observed changes in covariance structure result from the unfolding of inherent, random individual differences in the overall levels and rates of change in depression over time (random growth curves). The second assumes that observed changes are due to time-specific random effects (innovations) accumulating over time (autoregressive effects). We found little evidence of age-specific genetic effects or persistent genetic innovations. Instead, genetic effects are consistent with a gradual unfolding in the liability to depression and rates of change with increasing age. Likewise, the environment also creates significant individual differences in overall levels of depression and rates of change. However, there are also time-specific environmental experiences that persist with fidelity. The implications of these differing genetic and environmental mechanisms in the etiology of depression are considered.