Accessible Bifunctional Oxy-Tethered Ruthenium(II) Catalysts for Asymmetric Transfer Hydrogenation
Accessible Bifunctional Oxy-Tethered Ruthenium(II) Catalysts for Asymmetric Transfer Hydrogenation
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DOI：
10.1021/acs.orglett.8b02157
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发表时间：
2018-09-07
期刊：
影响因子：
5.2
通讯作者：
Kayaki, Yoshihito
中科院分区：
文献类型：
--
作者：
Matsunami, Asuka;Ikeda, Marika;Kayaki, Yoshihito
本文描述了一种用于芳香酮不对称转移氢化的新型氧连接钌配合物的简洁合成方法。该氧连接是通过全氟苯磺酰基取代基的分子内亲核取代所产生的脱氟醚化反应构建的。所获得的连接配合物表现出良好的催化活性和选择性，尤其是在官能化芳香酮的不对称转移氢化反应中。与未连接的原型配合物相比，连接的稳健性和刚性有助于其优越的催化性能。
A concise synthesis of new oxy-tethered ruthenium complexes effective for the asymmetric transfer hydrogenation of aromatic ketones is described. The oxy-tether was constructed via a defluorinative etherification arising from an intramolecular nucleophihc substitution of a perfluorinated phenylsulfonyl substituent. The obtained tethered complexes exhibited desirable catalytic activity and selectivity, especially in the asymmetric transfer hydrogenation of functionalized aromatic ketones. The robustness and rigidity of the tether contribute to their superior catalytic performance relative to the nontethered prototype complex.