STAPHYLOCOCCUS-AUREUS SKIN COLONIZATION IN ATOPIC-DERMATITIS PATIENTS
STAPHYLOCOCCUS-AUREUS SKIN COLONIZATION IN ATOPIC-DERMATITIS PATIENTS
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DOI：
10.1159/000249493
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
SCHOPFER, K
中科院分区：
文献类型：
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作者：
HAUSER, C;WUETHRICH, B;SCHOPFER, K
对21例特应性皮炎(AD)患者和22例健康人皮肤金黄色葡萄球菌的定植情况进行了比较。AD患者明显正常皮肤的总需氧菌计数、金黄色葡萄球菌比例和金黄色葡萄球菌携带率均显著高于健康人。从AD患者皮肤中分离的190株金黄色葡萄球菌对5种外用抗生素[呋西地酸、杆菌素、新霉素、四环素、红霉素]和青霉素进行了敏感性试验，结果表明，AD患者皮肤中金黄色葡萄球菌的密度是正常皮肤的100~1000倍。除了对受阿尔茨海默病影响的人造成的生物学后果外，这种金黄色葡萄球菌的严重定植具有流行病学上的重要性。几起金黄色葡萄球菌通过皮炎皮肤传播感染的暴发已被描述。因此，对其预防和治疗方面进行了讨论。
A study was conducted to compare the S. aureus skin colonization of 21 patients with atopic dermatitis (AD) and 22 healthy controls. The total aerobe count, the S. aureus fraction thereof and the S. aureus carrier frequency were significantly higher in apparently normal skin of AD patients than in healthy individuals. Compared to normal skin of patients S. aureus density was 100-1000 times higher in the 3 different kinds of lesional skin (dermatitic, lichenified and impetiginized sites); 190 S. aureus strains isolated from the skin of AD patients were tested for sensitivity to 5 topically used antibiotics [fusidic acid, bacitracin, neomycin, tetracycline and erythromycin] and to penicillin and the results reported. Besides the biological consequences for the person affected by AD, this severe colonization with S. aureus is of epidemiological importance. Several outbreaks of S. aureus infections by dispersal from dermatitic skin have been described. Therefore some preventive and therapeutic aspects are discussed.