Presetting Basal Ganglia for Volitional Actions
Presetting Basal Ganglia for Volitional Actions
复制标题
为意志行为预设基底神经节
DOI：
10.1523/jneurosci.1738-10.2010
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
D. Munoz
中科院分区：
文献类型：
--
作者：
Masayuki Watanabe;D. Munoz
基底神经节（BG）被认为是意志行为准备的关键结构。纹状体中的神经元是BG的主要输入阶段，在意志行动开始之前逐渐增加活动。然而，由于纹状体运动指令的多样性，如自动（感觉驱动）和意志（内部驱动）的行动，目前还不清楚是否有一组适当的神经元编码意志行动选择性激活意志行动的准备。在这里，使用antisaccade范例（看远离视觉刺激），我们分离神经元的尾状核，眼纹状体，编码主要是自动扫视向刺激和意志扫视在刺激的相反方向在猴子。我们发现，在实际的眼跳方向被定义的视觉刺激的外观，神经元编码的意志眼跳增加活动，随着时间的推移，从固定启动和固定点消失和刺激外观之间的时间间隔。他们的活动进一步提高了反突击指令和反突击行为相关。神经元编码的自动扫视也增加了活动，随着时间的推移，从固定启动和固定间隙。然而，这种类型的神经元的活动并没有增强的反突击指令，也不与反突击行为。我们的结论是，尾状核神经元整合非空间信号，如从固定启动，固定间隙，和任务指令，预设BG电路有利于意志的行动，甚至在自动和意志的命令与空间信息编程的自动行动竞争。
The basal ganglia (BG) have been considered as a key structure for volitional action preparation. Neurons in the striatum, the main BG input stage, increase activity gradually before volitional action initiation. However, because of the diversity of striatal motor commands, such as automatic (sensory driven) and volitional (internally driven) actions, it is still unclear whether an appropriate set of neurons encoding volitional actions are activated selectively for volitional action preparation. Here, using the antisaccade paradigm (look away from a visual stimulus), we dissociated neurons in the caudate nucleus, the oculomotor striatum, encoding predominantly automatic saccades toward the stimulus and volitional saccades in the opposite direction of the stimulus in monkeys. We found that before actual saccade directions were defined by visual stimulus appearance, neurons encoding volitional saccades increased activity with elapsed time from fixation initiation and by a temporal gap between fixation point disappearance and stimulus appearance. Their activity was further enhanced by an antisaccade instruction and correlated with antisaccade behavior. Neurons encoding automatic saccades also increased activity with elapsed time from fixation initiation and by a fixation gap. However, the activity of this type of neuron was not enhanced by an antisaccade instruction nor correlated with antisaccade behavior. We conclude that caudate neurons integrate nonspatial signals, such as elapsed time from fixation initiation, fixation gap, and task instructions, to preset BG circuits in favor of volitional actions to compete against automatic actions even before automatic and volitional commands are programmed with spatial information.
影响因子：
2.5
作者：
Hanes, DP;Patterson, WF;Schall, JD
通讯作者：
Schall, JD