RNA virus population diversity: implications for inter-species transmission
RNA virus population diversity: implications for inter-species transmission
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DOI：
10.1016/j.coviro.2011.09.012
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发表时间：
2011-12-01
影响因子：
5.9
通讯作者：
Vignuzzi, Marco
中科院分区：
文献类型：
--
作者：
Borderia, Antonio V.;Stapleford, Kenneth A.;Vignuzzi, Marco
RNA病毒以在单个复制周期中快速产生遗传多样性群体而闻名，这种突变群体（通常称为准种）的影响可能是巨大的。先前的研究已经将RNA病毒的遗传变异性与病毒发病机制的变化、在感染期间适应宿主的能力以及完全转换宿主所需的机制的获得联系起来。然而，这些初步研究只是开始。随着下一代技术的发展，研究小组将能够更深入地挖掘RNA病毒感染过程中产生的序列空间，并更清楚地了解病毒遗传多样性的发展、作用和后果。
RNA viruses are notorious for rapidly generating genetically diverse populations during a single replication cycle, and the implications of this mutant population, often referred to as quasispecies, can be vast. Previous studies have linked RNA virus genetic variability to changes in viral pathogenesis, the ability to adapt to a host during infection, and to the acquisition of mechanisms required to switch hosts entirely. However, these initial studies are just the beginning. With the development of next generation technologies, groups will be able to dig deeper into the sequence space that is generated during an RNA virus infection and more clearly understand the development, role, and consequences of viral genetic diversity.