Do chickens immunized with bacterial immunoglobulin G-binding proteins produce rheumatoid factor-like antibodies?
Do chickens immunized with bacterial immunoglobulin G-binding proteins produce rheumatoid factor-like antibodies?
复制标题
用细菌免疫球蛋白 G 结合蛋白免疫的鸡会产生类风湿因子抗体吗？
DOI：
10.1046/j.1365-3083.1998.00286.x
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发表时间：
1998
影响因子：
3.7
通讯作者：
Raeder,R
中科院分区：
文献类型：
--
作者：
Boyle,MD;Vogel,L;Sisson,S;Raeder,R
已经注意到用细菌免疫球蛋白（Ig）G结合蛋白免疫的动物产生类风湿因子（RF）样抗体之间的关联。目前提出了三种可能的解释：(1)与免疫原结合导致宿主IgG发生改变；(2)结合蛋白的B细胞超抗原特性；(3)独特型-抗独特型反应导致抗体作为抗原模拟物。为了区分这些可能性，有必要在IgG不与IgG结合蛋白免疫原发生反应的动物身上进行研究。因此，我们已经确定了用纯化的C组链球菌IgG结合蛋白FcRc（一种表达该蛋白的细菌）和适当的对照免疫原免疫鸡的效果。这些研究结果为用纯蛋白或表达该蛋白的细菌免疫的鸡群产生FcRc特异性抗体提供了证据。没有发现与RF样抗体产生的显著关联，这支持了RF样抗体与细菌IgG结合蛋白免疫之间关联的IgG结合改变的解释。
An association between the production of rheumatoid factor (RF)‐like antibodies in animals immunized with bacterial immunoglobulin (Ig)G‐binding proteins has been noted. Three potential explanations have been proposed: (1) altered host IgG due to binding of the immunogen; (2) B‐cell superantigenic properties of the binding proteins; and (3) idiotype‐anti‐idiotype response leading to an antibody which acts as an antigen mimic. In order to distinguish among these possibilities, it is necessary to carry out studies in animals whose IgG does not react with the IgG‐binding protein immunogen. Consequently, we have determined the effects of immunizing chickens with a purified group C streptococcal IgG‐binding protein, FcRc, a bacterium expressing this protein, and appropriate control immunogens. The results of these studies provided evidence for production of specific antibodies to FcRc in groups of chickens immunized with either the pure protein or bacteria expressing the protein. No significant association with production of RF‐like antibodies was noted, favouring the altered IgG‐binding explanation for the association between RF‐like antibodies and immunization with the bacterial IgG‐binding proteins.