Possible contribution of prostatic anterior fibromuscular stroma to age-related urinary disturbance in reference to pressure-flow study
Possible contribution of prostatic anterior fibromuscular stroma to age-related urinary disturbance in reference to pressure-flow study
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DOI：
10.1016/j.ultrasmedbio.2004.02.005
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发表时间：
2004-05-01
影响因子：
2.9
通讯作者：
Miki, T
中科院分区：
文献类型：
--
作者：
Ukimura, O;Iwata, T;Miki, T
最近，我们报道了前列腺前纤维肌间质（AFMS）与前列腺其他腺体区域相比具有显著不同的神经支配。在健康志愿者（n = 12）中，使用经直肠超声（US）或TRUS，在排尿期间监测，我们观察到AFMS厚度在排尿期间的动态变化（p < 0.0001）。本研究的目的是揭示AFMS对排尿的可能功能贡献，以及与年龄相关的排尿功能障碍。对56例排尿功能障碍的患者，在排尿过程中同时进行压力-流量测定（PFS）和TRUS监测，测量排尿过程中下尿路的超声动态变化。对于排尿功能障碍的老年男性，超声测量AFMS（p < 0.01）和尿道开口（p < 0.05）的动态变化有助于诊断阻塞性病变的解剖定位。无前列腺增生和膀胱颈梗阻的患者，AFMS运动不良可解释年龄相关性排尿障碍。（电子邮件：ukimura@koto.kpu-m.ac.jp）（C）2004年世界医学超声生物学联合会。
Recently, we reported that the anterior fibromuscular stroma (AFMS) of the prostate has significant different innervation compared with the other glandular regions of the prostate. In healthy volunteers (n = 12) using transrectal ultrasound (US), or TRUS, monitoring during voiding, we observed dynamic change (p < 0.0001) of the thickness of the AFMS during voiding. The aim of this study was to reveal the possible functional contribution of the AFMS to micturition, as well as the age-related voiding dysfunction. In the patients (n = 56) with voiding dysfunction who underwent both pressure-flow study (PFS) for determining obstruction and TRUS monitoring during voiding, we measured the ultrasonic dynamic change of the lower urinary tract during voiding. In old men with voiding dysfunction, ultrasonic measurements of dynamic change in the AFMS (p < 0.01) as well as the opening urethra (p < 0.05) could contribute to diagnosing of the anatomical localization of obstructive lesions. The poor movement of AFMS could account for the age-related urinary disturbance in the patients without benign prostatic enlargement and without bladder neck obstruction. (E-mail: ukimura@koto.kpu-m.ac.jp) (C) 2004 World Federation for Ultrasound in Medicine Biology.