Elevation of plasma endothelin associated with systemic hypertension in humans following orthotopic liver transplantation.
Elevation of plasma endothelin associated with systemic hypertension in humans following orthotopic liver transplantation.
复制标题
原位肝移植后血浆内皮素升高与人体全身性高血压相关。
DOI：
10.1097/00007890-199103000-00020
复制
发表时间：
1991
期刊：
影响因子：
6.2
通讯作者：
BurnettJr,JC
中科院分区：
文献类型：
--
作者：
Lerman,A;Click,RL;Narr,BJ;Wiesner,RH;Krom,RA;Textor,SC;BurnettJr,JC
内皮素 (ET) 是一种源自内皮的 21 个氨基酸肽，是一种有效的全身和肾血管收缩剂，与钠潴留和肾素-血管紧张素-醛固酮系统的调节相关。本研究旨在确定肝硬化患者 (n = 12) 的血浆 ET 是否升高，肝硬化是一种以钠潴留和血浆肾素活性 (PRA) 和血浆醛固酮 (PA) 增加为特征的疾病，并确定原位肝移植 (OLT) 对移植后 1、3 和 7 天血浆 ET、PRA 和 PA 的影响。 OLT 前血浆 ET 为 1.62+/-0.23 pg/ml，与正常对照相比没有差异。 OLT 后血浆 ET 分别显着增加至 4.18+/-0.66、3.87+/-0.58 和 4.07+/-0.61 pg/ml。 PRA 在整个术后过程中保持升高，而 PA 在 OLT 后下降。第 3 天和第 7 天，平均动脉压从 OLT 前的 82+/-4 mmHG 分别显着增加至 98+/-4 和 103+/-2 mmHG。
Endothelin (ET) is a 21-amino-acid peptide of endothelial origin, is a potent systemic and renal vasoconstrictor associated with sodium retention and modulation of the renin-angiotensin-aldosterone system. The present study was designed to determine if plasma ET is elevated in humans with cirrhosis (n= 12), a state characterized by sodium retention and increased plasma renin activity (PRA) and plasma aldosterone (PA), and to determine the effect of orthotopic liver transplantation (OLT) upon plasma ET, PRA, and PA at 1, 3, and 7 days after transplantation. Plasma ET before OLT was 1.62+/-0.23 pg/ml, which was not different as compared with normal controls. Plasma ET significantly increased to 4.18+/-0.66, 3.87+/-0.58, and 4.07+/-0.61 pg/ml, respectively following OLT. PRA remained elevated throughout the postoperative course, in contrast to PA that decreased following OLT. Mean arterial pressure increased significantly from 82+/-4 pre-OLT to 98+/-4 and 103+/-2 mmHG on days 3 and 7 respectively.