Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
复制标题
咪唑啉i2受体激动剂对复杂性诱导的痛觉过敏和大鼠抑郁样行为的影响。
DOI：
10.1097/fbp.0000000000000454
复制
发表时间：
2019-08
影响因子：
1.6
通讯作者：
Li JX
中科院分区：
文献类型：
--
作者：
Siemian JN;Shang L;Seaman RW Jr;Zhu Q;Zhang Y;Li JX
纤维肌痛的药物治疗缺乏。本研究探讨了咪唑啉I2受体（I2 R）激动剂在利血平诱导的大鼠纤维肌痛模型中的镇痛和抗抑郁样作用。大鼠用溶剂或利血平处理3天。使用von Frey细丝试验评估I2受体激动剂的抗伤害性作用，使用强迫游泳试验评估这些药物的抗抑郁样作用。2-BFI（3.2 - 10 mg/kg，腹腔注射），苯唑啉（17.8 - 56 mg/kg，i. p.）和CR4056（3.2 - 10mg/kg，i. p.）所有的剂量依赖性地产生显著的抗伤害感受作用，其被I2 R拮抗剂咪唑克生减弱。只有CR 4056显著减少了溶剂和利血平处理的大鼠在强迫游泳试验中的不动时间。这些数据表明，I2 R激动剂可能有助于治疗纤维肌痛相关疼痛和共病抑郁症。
Pharmacotherapies for fibromyalgia treatment are lacking. This study examined the antinociceptive and antidepressant-like effects of imidazoline I2 receptor (I2R) agonists in a reserpine-induced model of fibromyalgia in rats. Rats were treated for three days with vehicle or reserpine. The von Frey filament test was used to assess the antinociceptive effects of I2 receptor agonists, and the forced swim test was used to assess the antidepressant-like effects of these drugs. 2-BFI (3.2 – 10 mg/kg, i.p.), phenyzoline (17.8 – 56 mg/kg, i.p.) and CR4056 (3.2 – 10 mg/kg, i.p.) all dose-dependently produced significant antinociceptive effects, which were attenuated by the I2R antagonist idazoxan. Only CR4056 significantly reduced the immobility time in the forced swim test in both vehicle- and reserpine-treated rats. These data suggest that I2R agonists may be useful to treat fibromyalgia-related pain and comorbid depression.