DETERMINATION OF TRANSFER RATIO OF CATS GENICULATE NEURONS THROUGH QUASI-INTRACELLULAR RECORDINGS AND RELATION WITH LEVEL OF ALERTNESS
DETERMINATION OF TRANSFER RATIO OF CATS GENICULATE NEURONS THROUGH QUASI-INTRACELLULAR RECORDINGS AND RELATION WITH LEVEL OF ALERTNESS
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DOI：
10.1007/bf00816160
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发表时间：
1972-01-01
影响因子：
2
通讯作者：
VENDRIK, AJH
中科院分区：
文献类型：
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作者：
COENEN, AML;VENDRIK, AJH
1.对猫外侧膝状体神经元进行了准细胞内记录。2.实验结果表明，膝状体神经元的兴奋性输入来源于单一的视束纤维。3.实验是在非麻醉的麻痹猫上进行的，猫表现出不同的警觉水平，如睡眠、困倦和觉醒。在这些不同的水平，膝状体神经元的输入保持不变，但输出变化相当大。传递率，定义为神经元的尖峰频率（输出）和EPSP频率（输入）之间的比率，是高的（0.9-1.0）在清醒和低（0.4-0.5），中间值在中间状态。4.转移率的控制是通过改变EPSP的幅度来实现的，在清醒时几乎所有的EPSP都足够大，达到阈值;睡眠期间，EPSP小于阈值电位。EPSP幅值的变化可能与突触前抑制机制有关。5.根据警觉水平控制信息流向视皮层可能是外侧膝状体的功能之一。
1.Quasi-intracellular recordings from neurons in the lateral geniculate nucleus of the cat have been made. From these recordings the excitatory input of these neurons could be determined.2.The experiments suggest, that the excitatory input of a geniculate neuron is originating from one single optic tract fibre.3.The experiments were performed on non-anaesthetized paralyzed cats which showed different levels of alertness such as sleep, drowsiness and wakefulness. During these different levels the input of the geniculate neurons remains constant but the output varies considerable. Thetransfer ratio, defined as the ratio between the spike frequency (output) and the EPSP frequency (input) of a neuron is high (0.9–1.0) during wakefulness and low (0.4–0.5) during sleep with intermediate values at intermediate states.4.The control of the transfer ratio is caused bychanging the amplitude of the EPSPs.During wakefulness nearly all EPSPs are large enough to reach the threshold; duringsleepthe EPSPs are smaller than the threshold potential. A mechanism working like presynaptic inhibition might be responsible for the change of the EPSP amplitude.5.The control of the flow of information to the visual cortex according to the level of alertness is probably one of the functions of the lateral geniculate nucleus.