Survival in relation to radiotherapeutic modality for brain metastasis - Whole brain irradiation vs. gamma knife radiosurgery
Survival in relation to radiotherapeutic modality for brain metastasis - Whole brain irradiation vs. gamma knife radiosurgery
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DOI：
10.1097/01.coc.0000128863.75360.a5
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发表时间：
2004-08-01
影响因子：
2.6
通讯作者：
D'Agostino, H
中科院分区：
文献类型：
--
作者：
Datta, R;Jawahar, A;D'Agostino, H
本报告的目的是评估和比较脑转移瘤（BRM）患者的生存率，全脑照射（WBI）使用线性能量加速器（LINAC）和立体定向放射外科手术使用伽玛刀。本研究包括1998年至1999年期间接受WBI治疗的67例BRM患者和2000年至2001年期间接受伽玛刀放射外科（GKRS）治疗的53例BRM患者。对数据进行回顾性研究，并分析这两组之间的总生存率。通过卡方（2）和t检验值检验这2组的可比性。生存率比较采用对数秩检验。WBI组和GKRS组的1年生存率分别为26.3%和22.6%，平均生存期分别为7.8个月和6.7个月。这两组的生存率没有统计学显著差异。影像学明确的病变表明，GKRS治疗后，89%的病例病变缩小、稳定或消失。在这些系列中，接受WBI或GKRS治疗的BRM患者的生存率相似。目前的研究表明，GKRS的良好肿瘤反应并不意味着患者的生存期更长。
The purpose of this report is to evaluate and compare the survival of patients with brain metastasis (BRM) treated by whole brain irradiation (WBI) using linear energy accelerator (LINAC) and by stereotactic radiosurgery using gamma knife. This study consists of a series of 67 patients with BRM treated with WBI between 1998 and 1999 and 53 patients with BRM treated with gamma knife radiosurgery (GKRS) between 2000 and 2001. A retrospective study of the data was performed and the overall survival between these 2 groups was analyzed. The comparability of these 2 groups was tested by chi(2) and t test values. Log-rank test was used in the survival comparison. The 1-year survival rate was 26.3% and 22.6%, and corresponding mean survival was 7.8 months and 6.7 months for WBI and GKRS groups, respectively. There was no statistically significant difference between these 2 groups' survival. It was evident from imaging defined lesions that with GKRS the lesions were reduced, stabilized, or disappeared in 89% of cases. Survival of patients with BRM treated with WBI or GKRS was similar in these series. The present study suggests that good tumor response by GKRS does not translate in longer patient survival.