Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography
Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography
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DOI：
10.1016/j.clinph.2015.06.002
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发表时间：
2016-01-01
影响因子：
4.7
通讯作者：
Greger, Bradley
中科院分区：
文献类型：
--
作者：
Kellis, Spencer;Sorensen, Larry;Greger, Bradley
目的：皮质电图网格已被用于研究和诊断神经病理生理超过50年，最近已被用于各种神经假体的应用。在这里，我们提供的证据表明，微尺度电极更适合于研究皮层病理和功能，并为实现neural prostheses.Methods：这项工作比较动态的空间，时间和频率的皮层场电位记录的三种类型的电极：皮层电图（ECoG）电极，非穿透微ECoG（mu ECoG）电极，使用微电极，并有更紧密的电极间间距;和穿透微电极（MEA），其穿透皮层以记录单或多单位活动（SUA或MUA）和局部场电位（LFP）。结果：虽然在皮层内记录的LFP中发现了最精细的空间尺度，但我们发现从lECoG电极记录的LFP表现出线性相似性的尺度（即，相关性、相干性和相位）比临床ECoG电极更接近皮质内电极。结论：我们得出结论，LFP可以在皮质内和皮质上以比临床ECoG电极能够捕获的更精细的尺度记录。用适当比例的电极和网格记录，场电位揭示了皮层网络活动的更详细的表示，从而实现对皮层病理学的高级分析和诸如脑机接口的要求苛刻的应用。(C)2015年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Electrocorticography grids have been used to study and diagnose neural pathophysiology for over 50 years, and recently have been used for various neural prosthetic applications. Here we provide evidence that micro-scale electrodes are better suited for studying cortical pathology and function, and for implementing neural prostheses.Methods: This work compares dynamics in space, time, and frequency of cortical field potentials recorded by three types of electrodes: electrocorticographic (ECoG) electrodes, non-penetrating micro-ECoG (mu ECoG) electrodes that use microelectrodes and have tighter interelectrode spacing; and penetrating microelectrodes (MEA) that penetrate the cortex to record single-or multiunit activity (SUA or MUA) and local field potentials (LFP).Results: While the finest spatial scales are found in LFPs recorded intracortically, we found that LFP recorded from lECoG electrodes demonstrate scales of linear similarity (i.e., correlation, coherence, and phase) closer to the intracortical electrodes than the clinical ECoG electrodes.Conclusions: We conclude that LFPs can be recorded intracortically and epicortically at finer scales than clinical ECoG electrodes are capable of capturing.Significance: Recorded with appropriately scaled electrodes and grids, field potentials expose a more detailed representation of cortical network activity, enabling advanced analyses of cortical pathology and demanding applications such as brain-computer interfaces. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.