INHIBITION BY RETINOIC ACID OF COLLAGENASE PRODUCTION IN RHEUMATOID SYNOVIAL-CELLS
INHIBITION BY RETINOIC ACID OF COLLAGENASE PRODUCTION IN RHEUMATOID SYNOVIAL-CELLS
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DOI：
10.1056/nejm198008213030805
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发表时间：
1980-01-01
影响因子：
158.5
通讯作者：
HARRIS, ED
中科院分区：
文献类型：
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作者：
BRINCKERHOFF, CE;MCMILLAN, RM;HARRIS, ED
在类风湿性关节炎中，滑膜细胞响应发炎关节内产生的刺激而产生许多炎症介质。胶原酶和前列腺素 E2 是其中两种介质。两者都被认为会导致这种疾病中出现的破坏性病变。胶原酶可能是胶原蛋白降解的限速酶，胶原蛋白是软骨、肌腱、韧带和骨骼的主要结构蛋白123；类风湿组织的骨吸收活性主要由前列腺素E2负责。4类风湿滑膜细胞单层培养物合成并分泌大量胶原酶和前列腺素E2到培养基中。 。 。 。
IN rheumatoid arthritis, synovial cells produce many mediators of inflammation in response to stimuli generated within the inflamed joint. Collagenase and prostaglandin E2are two of these mediators. Both are thought to contribute to the destructive lesions seen in this disease. Collagenase may be the rate-limiting enzyme in the degradation of collagen, which is the principal structural protein of cartilage, tendon, ligaments, and bone123; and prostaglandin E2accounts for most of the bone-resorbing activity of rheumatoid tissue.4Monolayer cultures of rheumatoid synovial cells synthesize and secrete large amounts of collagenase and prostaglandin E2into culture medium. . . .