Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain
Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain
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DOI：
10.2217/nnm-2018-0372
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发表时间：
2019-05-01
期刊：
影响因子：
5.5
通讯作者：
Uskokovic, Vuk
中科院分区：
文献类型：
--
作者：
Adamiano, Alessio;Wu, Victoria M.;Uskokovic, Vuk
目的：磁热疗受到散布在健康组织内的肿瘤细胞的低选择性敏感性的限制，我们的目标是改进这一点。材料与方法：合成了两种超顺磁性磷酸钙纳米复合材料，即铁掺杂羟基磷灰石和涂有无定形磷酸钙（Mag@CaP）的氧化铁（Mag）纳米粒子，并测试了其针对脑癌和骨癌的选择性活性。结果：纳米颗粒的摄取和细胞内定位是在极低功率的交替磁场中降低癌症活力的先决条件。外膜上的纯粹吸附不足以产生这种效应，这对于 Mag@CaP 和铁掺杂羟基磷灰石极其重要，但对于 Mag 来说可以忽略不计，这证明了磁性铁与磷酸钙结合的好处。结论：这种选择性效应对于全球振兴磁热疗临床前景的努力非常重要。
Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate (Mag@CaP), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for Mag@CaP and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.