Mega-dose vitamin C in treatment of the common cold: a randomised controlled trial
Mega-dose vitamin C in treatment of the common cold: a randomised controlled trial
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DOI：
10.5694/j.1326-5377.2001.tb143618.x
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发表时间：
2001-10-01
影响因子：
11.4
通讯作者：
Douglas, RM
中科院分区：
文献类型：
--
作者：
Audera, C;Patulny, RV;Douglas, RM
目的：探讨大剂量维生素C治疗感冒的疗效。研究设计：4个干预组的双盲随机临床试验：维生素C每日0.03g(安慰剂)、1g、3g或3g加添加剂(Bio-C)，在感冒开始时服用，持续两天。参与者和地点：于1998年5月至1999年11月从澳大利亚堪培拉国立大学的教职员工和学生中招募400名健康志愿者。试验持续18个月。干预：受试者在经历感冒早期症状4小时后开始服药，并记录他们的症状、严重程度、就诊和其他药物的使用。主要观察指标：症状和感冒发作的持续时间；7、14和28天的累积症状严重程度评分；看医生；以及参与者是否猜测他们正在服用哪种药物。结果：149名参与者返回了184次感冒发作的记录。在四个用药组之间，感冒持续时间或严重程度的任何衡量标准都没有显著差异。虽然差异不显著，但安慰剂组的鼻部、全身和整体症状持续时间最短，平均严重程度评分在第14天最低，在第7天和第28天次之。结论：与低于最低推荐日摄入量的维生素C相比，感冒后不久每日服用1g以上的维生素C并不能缩短健康成年志愿者感冒症状的持续时间和严重程度。
Objective: To determine the effect of large doses of vitamin C in the treatment of the common cold.Study design: Double-blind, randomised clinical trial with four intervention arms: vitamin C at daily doses of 0.03 g ("placebo"), 1 g, 3 g, or 3 g with additives ("Bio-C") taken at onset of a cold and for the following two days.Participants and setting: 400 healthy volunteers were recruited from staff and students of the Australian National University, Canberra, ACT, between May 1998 and November 1999. The trial continued for 18 months.Interventions: Participants were instructed to commence medication when they had experienced early symptoms of a cold for four hours, and to record daily their symptoms, severity, doctor visits and use of other medications.Main outcome measures: Duration of symptoms and cold episodes; cumulative symptom severity scores after 7, 14 and 28 days; doctor visits; and whether participants guessed which medication they were taking.Results: 149 participants returned records for 184 cold episodes. No significant differences were observed in any measure of cold duration or severity between the four medication groups. Although differences were not significant, the placebo group had the shortest duration of nasal, systemic and overall symptoms, and the lowest mean severity score at 14 days, and the second lowest at 7 and 28 days.Conclusions: Doses of vitamin C in excess of 1 g daily taken shortly after onset of a cold did not reduce the duration or severity of cold symptoms in healthy adult volunteers when compared with a vitamin C dose less than the minimum recommended daily intake.