Defibrotide: a Swiss Army knife intervention in the battle against cerebral malaria.
Defibrotide: a Swiss Army knife intervention in the battle against cerebral malaria.
复制标题
去纤苷：对抗脑型疟疾的瑞士军刀干预。
DOI：
10.1161/atvbaha.111.242776
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Avery,JohnW
中科院分区：
文献类型：
--
作者：
Moore,JulieM;Avery,JohnW
Cerebral malaria (CM) is a severe manifestation of Plas-modium falciparum infection, characterized by seizures and coma, respiratory distress, hypoglycemia, and acidosis. Intensely studied for decades, important advances in understanding this clinically complex syndrome have been achieved, but highly efficacious treatment remains elusive. 1 Even with rapid delivery of antimalarial drugs on diagnosis and the best supportive care, many CM victims do not survive. 1 An effective malaria vaccine to prevent CM and other severe malaria syndromes is not yet available, making continued efforts to identify novel therapies, particularly those that can serve as adjuncts to antimalarial drugs, essential. 2 Defibrotide (DF), a mixture of single-stranded 50-mer DNA aptamers with a minor component of double stranded DNA that is derived from depolymerized mammalian genomic DNA, 3–5 is an exciting potential new recruit to the ranks of such adjunctive treatments. This multipotent drug displays endothelial-protective, antiischemic, anti-inflammatory, and mild anticoagulant effects and has been successfully used to treat comatose children experiencing veno-occlusive disease. 3–5
