Sensory Cortical Control of a Visually Induced Arrest Behavior via Corticotectal Projections.
Sensory Cortical Control of a Visually Induced Arrest Behavior via Corticotectal Projections.
复制标题
DOI：
10.1016/j.neuron.2015.03.048
复制
发表时间：
2015-05-06
期刊：
影响因子：
16.2
通讯作者：
Tao HW
中科院分区：
文献类型：
--
作者：
Liang F;Xiong XR;Zingg B;Ji XY;Zhang LI;Tao HW
受到威胁的感觉刺激所诱发的先天防御行为是动物生存所必需的。尽管皮层下回路与idb有关，但感觉皮层是否调节idb以及潜在的神经通路是什么仍不清楚。在这里，我们发现从小鼠初级视觉皮层（V1）第5层（L5）到上丘（SC）的皮质顶叶投影的光遗传沉默显著减少了SC依赖的先天行为，即在短至毫秒的突然闪光下暂时停止运动。令人惊讶的是，与其他主要的L5皮质投射相比，光遗传学激活的V1中的SC投射神经元或它们在SC中的轴突末梢充分引发了这种行为。因此，通过同样的皮质投射，视觉皮层不仅可以调节光诱导的捕获行为，还可以直接驱动该行为。我们的研究结果表明，感觉皮层可能在自上而下的感觉运动行为启动中发挥了以前未被认识到的作用。
Innate defense behaviors (IDBs) evoked by threatening sensory stimuli are essential for animal survival. Although subcortical circuits are implicated in IDBs, it remains largely unclear whether sensory cortex modulates IDBs and what are the underlying neural pathways. Here, we show that optogenetic silencing of corticotectal projections from layer 5 (L5) of the mouse primary visual cortex (V1) to the superior colliculus (SC) significantly reduces a SC-dependent innate behavior, i.e. temporary suspension of locomotion upon a sudden flash of light as short as milliseconds. Surprisingly, optogenetic activation of SC-projecting neurons in V1 or their axon terminals in SC sufficiently elicits the behavior, in contrast to other major L5 corticofugal projections. Thus, via the same corticofugal projection, visual cortex not only modulates the light-induced arrest behavior, but also can directly drive the behavior. Our results suggest that sensory cortex may play a previously unrecognized role in the top-down initiation of sensory-motor behaviors.