Decrease in Serum Adiponectin Levels Associated with Visceral Fat Accumulation Independent of Pubertal Stage in Children and Adolescents
Decrease in Serum Adiponectin Levels Associated with Visceral Fat Accumulation Independent of Pubertal Stage in Children and Adolescents
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DOI：
10.1016/j.arcmed.2011.03.002
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发表时间：
2011-02-01
影响因子：
7.7
通讯作者：
Torres-Tamayo, Margarita
中科院分区：
文献类型：
--
作者：
Medina-Bravo, Patricia;Meza-Santibanez, Ruth;Torres-Tamayo, Margarita
背景和目标。儿童肥胖是胰岛素抵抗(IR)及其共病的重要危险因素。然而，内脏脂肪组织(VAT)而不是肥胖似乎在IR的发展中起决定性作用。脂联素被认为是抵抗IR相关代谢异常的关键分子。一些研究已经证明，较低的脂联素浓度与增值税有关，但结果仍有争议。我们开展了这项研究，以评估增值税和脂联素浓度与儿童和青少年的体重指数(BMI)和青春期阶段的关系。85名受试者(46名青春期前和39名青春期)根据BMI分为肥胖组和正常体重组。所有参与者都接受了临床检查。测定血糖、胰岛素、血脂和脂联素。用螺旋CT计算增值税。在青春期前组中，肥胖儿童的脂联素浓度低于非肥胖儿童(p
Background and Aims. Childhood obesity is an important risk factor for the development of insulin resistance (IR) and its co-morbidities. However, visceral adipose tissue (VAT) rather than obesity appears to have a determining role in the development of IR. Adiponectin is considered a key molecule for protection against metabolic abnormalities related to IR. Several studies have documented that lower adiponectin concentrations are related to VAT, but the results are still controversial. We undertook this study to assess the association between VAT and adiponectin concentrations with respect to body mass index (BMI) and pubertal stage in children and adolescents.Methods. Eighty five subjects were studied (46 prepubertal and 39 pubertal) and classified according to BMI into obese and normal weight groups. All participants were given a clinical examination. Glucose, insulin, lipid profile and adiponectin were measured. VAT was estimated using helical computed tomography.Results. In the prepubertal group, obese children had lower adiponectin concentrations than nonobese subjects (p