Global analysis of gene expression in the estrogen induced pituitary tumor of the F344 rat.
Global analysis of gene expression in the estrogen induced pituitary tumor of the F344 rat.
复制标题
F344 大鼠雌激素诱导垂体瘤基因表达的整体分析。
DOI：
10.1016/j.jsbmb.2006.06.025
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Land,Susan
中科院分区：
文献类型：
--
作者：
Wendell,DouglasL;Platts,Adrian;Land,Susan
The F344 rat rapidly forms large prolactinomas in response to chronic estrogen treatment. To identify genes expressed in the course of this estrogen induced pituitary tumor growth, we performed microarray analysis on the F344 rat pituitary after chronic estrogen treatment and on untreated controls. At a significance level set to minimize type I error, some 72 genes were found to be differentially expressed between estrogen treated and untreated. Of those genes, 70 have not been reported previously as being affected by estrogen in the F344 rat pituitary. Since many other investigators have studied the effect of estrogen on specific gene expression in rat pituitary, we also examined the mRNA expression of the 36 genes that have been previously reported as having their expression affected by estrogen in the rat pituitary. Of these, 13 were found to have their expression affected by estrogen treatment in the same direction as had been reported by others.
