Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.
Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.
复制标题
追求精确医学：阿尔茨海默病小鼠模型的系统生物学方法。
DOI：
10.1016/j.nbd.2021.105558
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发表时间：
2021-12
影响因子：
6.1
通讯作者：
Kaczorowski, Catherine
中科院分区：
文献类型：
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作者：
Gurdon, Brianna;Kaczorowski, Catherine
Alzheimer’s disease (AD) is a complex disease that is mediated by numerous factors and manifests in various forms. A systems biology approach to studying AD involves analyses of various body systems, biological scales, environmental elements, and clinical outcomes to understand the genotype to phenotype relationship that potentially drives AD development. Currently, there are many research investigations probing how modifiable and nonmodifiable factors impact AD symptom presentation. This review specifically focuses on how imaging modalities can be integrated into systems biology approaches using model mouse populations to link brain level functional and structural changes to disease onset and progression. Combining imaging and omics data promotes the classification of AD into subtypes and paves the way for precision medicine solutions to prevent and treat AD.
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影响因子：
4
作者：
Ard, M. Colin;Edland, Steven D.
通讯作者：
Edland, Steven D.
影响因子：
15.8
作者：
Ahn AC;Tewari M;Poon CS;Phillips RS
通讯作者：
Phillips RS
影响因子：
4
作者：
Ardekani, Babak A.;Convit, Antonio;Bachman, Alvin H.
通讯作者：
Bachman, Alvin H.
影响因子：
14
作者：
通讯作者：
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影响因子：
14
作者：
通讯作者：
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