Neonatal serum magnesium concentrations are determined by total maternal dose of magnesium sulfate administered for neuroprotection
Neonatal serum magnesium concentrations are determined by total maternal dose of magnesium sulfate administered for neuroprotection
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DOI：
10.1515/jpm-2013-0151
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发表时间：
2014-03-01
影响因子：
2.4
通讯作者：
Rastogi, Shantanu
中科院分区：
文献类型：
--
作者：
Borja-Del-Rosario, Pamela;Basu, Sudeepta Kumar;Rastogi, Shantanu
Background: Antenatal magnesium in preterm labor for neuroprotection decreases the incidence of cerebral palsy. However, there are no guidelines on the dose and duration of magnesium infusion for neuroprotection. As increased neonatal serum magnesium concentrations may be related to higher risk of morbidity and mortality, the role of total amount of magnesium and maternal serum magnesium concentrations associated with safe neonatal serum magnesium concentrations is not known.Methods: A retrospective study was conducted on 289 mothers who received antenatal magnesium for neuroprotection as a loading dose of 4-6 g infused over 30 min, followed by a maintenance infusion of 1-2 g/h. Total magnesium dose infused to the mother and maternal serum magnesium concentrations were correlated with neonatal serum magnesium concentrations.Results: Of the 289 mothers, 192 mother/baby dyads had all three measurements (maternal total magnesium dose, and maternal and neonatal serum magnesium concentrations). Magnesium infusion was continued beyond 24 h in 60 mothers. Total maternal magnesium dose at 24 and 48 h of infusion correlated with neonatal serum magnesium concentrations (r=0.55, P
