ATTENUATION OF AVERSIVE PROPERTIES OF PERIPHERAL SHOCK BY HYPOTHALAMIC STIMULATION
ATTENUATION OF AVERSIVE PROPERTIES OF PERIPHERAL SHOCK BY HYPOTHALAMIC STIMULATION
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DOI：
10.1126/science.149.3681.323
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发表时间：
1965-01-01
期刊：
影响因子：
56.9
通讯作者：
VALENSTEIN, ES
中科院分区：
文献类型：
--
作者：
COX, VC;VALENSTEIN, ES
对正性脑刺激缓解疼痛的临床报道进行了实验研究。在一个双室测试室中的大鼠寻求下丘脑刺激，并通过一个网格扰频装置逃脱了令人厌恶的足部电击。动物们还寻求成对的下丘脑刺激和足部电击。对照实验表明，动物不区分下丘脑刺激和成对的下丘脑刺激和足部电击支持下丘脑刺激减弱足部电击的厌恶性质的观点。
Clinical reports of alleviation of pain with positive brain stimulation were investigated experimentally. Rats in a two-compartment testing chamber sought out hypothalamic stimulation and escaped from aversive foot shock delivered through a grid-scrambling device. Animals also sought out paired hypothalamic stimulation and foot shock. Control experiments demonstrating that animals did not discriminate between hypothalamic stimulation and paired hypothalamic stimulation and foot shock supported the view that hypothalamic stimulation attenuates the aversive properties of foot shock.