Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus
Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus
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DOI：
10.1016/j.jacl.2012.05.005
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发表时间：
2012-08-01
影响因子：
4.4
通讯作者：
Jones, Michael R.
中科院分区：
文献类型：
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作者：
Goldberg, Ronald B.;Rosenson, Robert S.;Jones, Michael R.
背景技术背景：胆汁酸螯合剂考来维仑已被证明可显著降低原发性高脂血症或2型糖尿病（T2 DM）成人患者的低密度脂蛋白颗粒浓度（LDL-P）。目的：评估二甲双胍联合考来维仑初始联合治疗对T2 DM患者脂蛋白颗粒的影响（次要疗效变量）。这项为期16周的随机、双盲、安慰剂对照研究入组了未接受过药物治疗的T2 DM成人患者，糖化血红蛋白6.5%-10.0%，低密度脂蛋白胆固醇（LDL-C）>= 100 mg/dL，甘油三酯
BACKGROUND: The bile acid sequestrant colesevelam has been shown to significantly reduce low-density lipoprotein particle concentration (LDL-P) in adults with primary hyperlipidemia or type 2 diabetes mellitus (T2DM).OBJECTIVE: To assess the effect of initial combination therapy with metformin plus colesevelam on lipoprotein particles in patients with T2DM (secondary efficacy variables).METHODS: This 16-week, randomized, double-blind, placebo-controlled study enrolled drug-naive adults with T2DM, glycated hemoglobin 6.5%-10.0%, low-density lipoprotein cholesterol (LDL-C) >= 100 mg/dL, and triglycerides