Gene x Environment Interactions in Type 2 Diabetes
Gene x Environment Interactions in Type 2 Diabetes
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DOI：
10.1007/s11892-011-0224-9
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发表时间：
2011-12-01
影响因子：
4.2
通讯作者：
Franks, Paul W.
中科院分区：
文献类型：
--
作者：
Franks, Paul W.
人们对许多疾病的环境风险因素的易感性因遗传而异。遗传变异也是人们对临床治疗做出适当反应的程度的基础。确定基因组与环境之间相互作用的基础可能有助于阐明2型糖尿病等疾病的生物学基础，并有助于靶向预防性治疗和治疗。本文综述了1）基因与环境相互作用与2型糖尿病相关的一些最新证据; 2）概述了基因与环境相互作用信息的可用性如何有助于改善2型糖尿病的预防和治疗; 3）讨论了现有和新兴的策略，这些策略可能会增强我们在复杂疾病特征中检测和利用基因与环境相互作用的能力。
People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene x environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene x environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene x environment interactions in complex disease traits.