Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
复制标题
DOI：
10.1016/j.bmcl.2006.04.068
复制
发表时间：
2006-07-15
影响因子：
2.7
通讯作者：
Hungate, Randall
中科院分区：
文献类型：
--
作者：
Burli, Roland W.;Xu, Han;Hungate, Randall
我们报告的人甲酰肽样1受体（hFPRL 1）的有效激动剂的发现。这些化合物在浓度高达10 μ M时不作用于表示为人甲酰肽受体（hFPR）的密切相关的受体。最近的研究表明，激动这种受体可以促进炎症的消退。在一项探索性研究中，一种新型hFPRL 1激动剂在口服给药后的小鼠耳部炎症模型中显示出疗效。(c)2006爱思唯尔有限公司版权所有。
We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 mu M concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration. (c) 2006 Elsevier Ltd. All rights reserved.