A supramolecular hydrogel for spatial-temporal release of auxin to promote plant root growth
A supramolecular hydrogel for spatial-temporal release of auxin to promote plant root growth
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超分子水凝胶可时空释放生长素促进植物根部生长
DOI：
10.1039/c8cc05999c
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发表时间：
2018
影响因子：
4.9
通讯作者：
Yang Zhimou
中科院分区：
文献类型：
--
作者：
Chen Yaoxia;Li Xinjing;Bai Jing;Shi Fang;Xu Tengyan;Gong Qingqiu;Yang Zhimou
基于短肽的水凝胶由于其响应特性而在药物递送方面引起了广泛的研究兴趣。到目前为止，大多数药物分子通过酰胺键与短肽缀合，限制了天然药物分子的释放。在这项研究中，我们证明了生长素为基础的水凝胶因子连接的水解酯键的有效性。凝胶因子（NAA-G′FFY）与酯键连接形成的水凝胶I能够释放1-萘乙酸（NAA），而凝胶因子（NAA-GFFY）与酯键不连接形成的水凝胶II则不能。通过将NAA-G′FFY与Fmoc-GFFY混合形成双组分水凝胶，实现了NAA的时空释放，促进了模式植物拟南芥中生长素的原位反应，包括主根伸长和侧根形成。利用可水解的酯键连接药物分子和自组装肽的策略可能导致具有更可控的药物释放曲线的超分子水凝胶的发展。
Short peptide-based hydrogels have attracted extensive research interests in drug delivery because of their responsive properties. So far, most drug molecules have been conjugated with short peptides via an amide bond, restricting the release of the native drug molecules. In this study, we demonstrated the effectiveness of an auxin-based hydrogelator linked by a hydrolysable ester bond. Hydrogel I, formed by the gelator (NAA-G′FFY) linked with an ester bond, was able to release 1-naphthaleneacetic acid (NAA), whereas hydrogel II, formed by the gelator without an ester bond (NAA-GFFY), was not. By mixing NAA-G′FFY with Fmoc-GFFY to form a two-component hydrogel, the spatial and temporal release of NAA was achieved, promoting on-site auxin responses including primary root elongation and lateral root formation in the model plant Arabidopsis thaliana. The strategy of using a hydrolysable ester bond to connect drug molecules and self-assembling peptides could lead to the development of supramolecular hydrogels with more controllable drug release profiles.