"Small Talk" in the Innate Immune System via RNA-Containing Extracellular Vesicles.
"Small Talk" in the Innate Immune System via RNA-Containing Extracellular Vesicles.
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DOI：
10.3389/fimmu.2014.00542
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发表时间：
2014
影响因子：
7.3
通讯作者：
Nolte-'t Hoen EN
中科院分区：
文献类型：
--
作者：
van der Grein SG;Nolte-'t Hoen EN
一种新发现的细胞间通讯方式涉及到由脂质、蛋白质和遗传物质组成的纳米细胞外囊泡（EV）的细胞间转移。免疫系统细胞释放的EV在诱导和抑制免疫应答中起调节作用。这些功能可能不仅由EV中存在的生物活性脂质和蛋白质介导，还可能由EV相关rna介导。EV中的RNA主要由microrna和大量其他小的非编码RNA组成。由于许多这些小rna具有调节基因表达的潜力，这些rna通过EV的细胞间转移可能会导致EV靶向细胞功能的长期变化。几种类型的先天免疫细胞释放影响先天免疫反应和其他（病理）生理过程的EV。此外，先天免疫系统受非免疫细胞释放的EV和体液中发现的EV的影响。在这篇综述中，我们关注ev相关rna如何参与这些免疫调节过程。
A newly uncovered means of communication between cells involves intercellular transfer of nano-sized extracellular vesicles (EV), composed of lipids, proteins, and genetic material. EV released by cells of the immune system can play a regulatory role in the induction and suppression of immune responses. These functions may be mediated not only by the bioactive lipids and proteins present in EV but also by EV-associated RNAs. The RNA in EV mainly consists of microRNAs and a large range of other small non-coding RNA species. Since many of these small RNAs have the potential to regulate gene expression, intercellular transfer of these RNAs via EV may cause long-term changes in the function of EV-targeted cells. Several types of innate immune cells release EV that affect innate immune responses and other (patho)physiological processes. Additionally, the innate immune system is influenced by EV released by non-immune cells and EV found in body fluids. In this review, we focus on how EV-associated RNAs contribute to these immune regulatory processes.
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影响因子：
4.8
作者：
Gourzones C;Gelin A;Bombik I;Klibi J;Vérillaud B;Guigay J;Lang P;Témam S;Schneider V;Amiel C;Baconnais S;Jimenez AS;Busson P
通讯作者：
Busson P
影响因子：
4.4
作者：
Batagov AO;Kuznetsov VA;Kurochkin IV
通讯作者：
Kurochkin IV
影响因子：
16
作者：
Crescitelli R;Lässer C;Szabó TG;Kittel A;Eldh M;Dianzani I;Buzás EI;Lötvall J
通讯作者：
Lötvall J
影响因子：
3.9
作者：
Gezer, Ugur;Ozgur, Emre;Dalay, Nejat
通讯作者：
Dalay, Nejat
DOI：
10.1073/pnas.1209414109
发表时间：
2012-07-31
影响因子：
11.1
作者：
Fabbri, Muller;Paone, Alessio;Croce, Carlo M.
通讯作者：
Croce, Carlo M.