Combination of human leukocyte antigen and killer cell immunoglobulin-like receptor genetic background influences the onset age of hepatocellular carcinoma in male patients with hepatitis B virus infection.
Combination of human leukocyte antigen and killer cell immunoglobulin-like receptor genetic background influences the onset age of hepatocellular carcinoma in male patients with hepatitis B virus infection.
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人白细胞抗原与杀伤细胞免疫球蛋白样受体遗传背景的组合影响乙型肝炎病毒感染男性患者肝细胞癌的发病年龄
DOI：
10.1155/2013/874514
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发表时间：
2013
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Pan N;Qiu J;Sun H;Miao F;Shi Q;Xu J;Jiang W;Jin H;Xie W;He Y;Zhang J
为探讨杀伤细胞免疫球蛋白样受体（KIR）和人类白细胞抗原（HLA）基因背景是否影响B型肝炎病毒（HBV）感染患者肝细胞癌（HCC）的发病年龄。分别检测到12个KIR位点。HLA-A、-B和-C位点通过常规的基于序列的分型方法以高分辨率进行基因分型。通过Kaplan-Meier（KM）分析单独检查每个KIR基因座、HLA配体和HLA-KIR组合的作用。多因素考克斯风险回归模型也被应用。我们将C1 C1-KIR 2DS 2/2DL 2确定为HCC早期发病年龄的独立危险因素（C1 C1-KIR 2DS 2/2DL 2阳性患者的中位发病年龄为44岁，而阴性患者为50岁，KM分析P = 0.04;多变量考克斯模型HR = 1.70，P = 0.004）。我们认为，KIR和HLA遗传背景可以影响男性HBV感染者肝癌的发病年龄。这项研究可能有助于改善目前HBV感染患者的HCC监测计划。我们的研究结果还表明，自然杀伤细胞（或其他KIR表达细胞）在HBV相关的HCC发展过程中起着重要作用。
To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled. The presence of 12 loci of KIR was detected individually. HLA-A, -B, and -C loci were genotyped with high resolution by a routine sequence-based typing method. The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis. Multivariate Cox hazard regression model was also applied. We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P = 0.04 for KM analysis; HR = 1.70, P = 0.004 for multivariate Cox model). We conclude that KIR and HLA genetic background can influence the onset age of HCC in male patients with HBV infection. This study may be useful to improve the current HCC surveillance program in HBV-infected patients. Our findings also suggest an important role of natural killer cells (or other KIR-expressing cells) in the progress of HBV-related HCC development.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
--
作者：
Hong HA;Loubser AS;de Assis Rosa D;Naranbhai V;Carr W;Paximadis M;Lewis DA;Tiemessen CT;Gray CM
通讯作者：
Gray CM
影响因子：
4.4
作者：
Foley, Bree;De Santis, Dianne;Witt, Campbell
通讯作者：
Witt, Campbell
DOI：
10.1084/jem.20061287
发表时间：
2007-03-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dunn C;Brunetto M;Reynolds G;Christophides T;Kennedy PT;Lampertico P;Das A;Lopes AR;Borrow P;Williams K;Humphreys E;Afford S;Adams DH;Bertoletti A;Maini MK
通讯作者：
Maini MK
DOI：
10.1084/jem.181.3.1133
发表时间：
1995-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gumperz JE;Litwin V;Phillips JH;Lanier LL;Parham P
通讯作者：
Parham P