Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
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Rnr 位于 1 号染色体上，Rnr 是调节小鼠颌下腺肾素的基因。
DOI：
10.1073/pnas.75.11.5623
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发表时间：
1978
影响因子：
11.1
通讯作者：
B. Taylor
中科院分区：
文献类型：
--
作者：
C. Wilson;E. G. Erdös;J. Wilson;B. Taylor
测定了4组重组近交系小鼠颌下腺提取液的肾素活性(EC3.4.99.19)。在51个重组近交系中，只有1个在RnR和Dip-1染色体标记基因之间存在重组，表明这两个基因在1号染色体上紧密连锁。在所有重组近交系中，雄激素处理的雌性小鼠的肾素活性与其中一个或另一个祖先品系相似，如果是单个基因起作用的，这是预期的。有文献表明，单个基因可以对小鼠颌下腺中的肾素产生重大影响，这意味着单基因差异可能解释了其他物种中肾素的已知变异。
Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.