Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.
Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.
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DOI：
10.1006/geno.1997.4656
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发表时间：
1997-05
期刊：
影响因子：
4.4
通讯作者：
Eduardo A. Garcia-Zepeda;Eduardo A. Garcia-Zepeda;Marc E. Rothenberg;S. Weremowicz;M. N. Sarafi;M. N. Sarafi;Cynthia C. Morton;Andrew D. Luster;Andrew D. Luster
中科院分区：
文献类型：
--
作者：
Eduardo A. Garcia-Zepeda;Eduardo A. Garcia-Zepeda;Marc E. Rothenberg;S. Weremowicz;M. N. Sarafi;M. N. Sarafi;Cynthia C. Morton;Andrew D. Luster;Andrew D. Luster
嗜酸性粒细胞趋化因子是CC趋化因子，其是嗜酸性粒细胞的特异性化学引诱物，并且涉及嗜酸性粒细胞炎性疾病（例如哮喘）的发病机制。我们描述的基因组组织，完整的序列，包括1354 bp的5'的RNA起始位点，和染色体定位的人嗜酸细胞活化趋化因子基因。荧光原位杂交分析将嗜酸性粒细胞趋化因子定位于人类17号染色体q21.1-q21.2区域，并将人类基因命名为SCYA 11。我们还提出了小鼠嗜酸性粒细胞趋化因子基因的5'侧翼序列，并确定了几个调节元件，是保守的鼠和人的启动子之间。特别是，元件如NF-κ B、干扰素-γ反应元件和糖皮质激素反应元件的存在可以解释所观察到的细胞因子和糖皮质激素对嗜酸性粒细胞趋化因子基因的调节。
Eotaxin is a CC chemokine that is a specific chemoattractant for eosinophils and is implicated in the pathogenesis of eosinophilic inflammatory diseases, such as asthma. We describe the genomic organization, complete sequence, including 1354 bp 5' of the RNA initiation site, and chromosomal localization of the human eotaxin gene. Fluorescence in situ hybridization analysis localized eotaxin to human chromosome 17, in the region q21.1-q21.2, and the human gene name SCYA11 was assigned. We also present the 5' flanking sequence of the mouse eotaxin gene and have identified several regulatory elements that are conserved between the murine and the human promoters. In particular, the presence of elements such as NF-kappa B, interferon-gamma response element, and glucocorticoid response element may explain the observed regulation of the eotaxin gene by cytokines and glucocorticoids.