Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia:: a proton magnetic resonance spectroscopy study
Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia:: a proton magnetic resonance spectroscopy study
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DOI：
10.1016/s0304-3940(00)01264-7
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发表时间：
2000-08-04
影响因子：
2.5
通讯作者：
Falkai, P
中科院分区：
文献类型：
--
作者：
Block, W;Bayer, TA;Falkai, P
神经病理学和神经影像学研究表明精神分裂症存在神经元功能障碍。 N-乙酰天冬氨酸 (NAA) 是神经元功能障碍的有用标志物，可以通过磁共振波谱 (MRS) 进行测量。在本研究中，对家族性精神分裂症受试者、混合精神病诊断家庭成员、未受影响的家庭成员和社区对照受试者的左额叶和基底神经节的 NAA、胆碱 (Cho)、磷酸肌酸 ((P)Cr)、含肌醇化合物和谷氨酰胺/谷氨酸 (Glx) 进行了评估。分析代谢物的浓度并以比率表示。含有 NAA/Cho、NAA/(P)Cr 和 Glx 的化合物与额叶年龄呈负相关。年龄共变后，与未受影响的家庭成员 (P = 0.018) 以及社区非家族对照 (P = 0.037) 对照相比，精神分裂症受试者的左额叶 NAA/Cho 比率显着降低。这些 MRS 观察结果支持了精神分裂症患者额叶存在与疾病相关的神经元缺陷以及基底神经节相对正常的假设。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Neuropathological and neuroimaging studies suggest neuronal dysfunction in schizophrenia. N-acetyl aspartate (NAA) is a useful marker of neuronal dysfunction that can be measured with magnetic resonance spectroscopy (MRS). In the present study NAA, choline (Cho), phospho-creatine ((P)Cr), inositol containing compounds and glutamine/glutamate (Glx) were assessed in the left frontal robe and basal ganglia of subjects with familial schizophrenia, family members with mixed psychiatric diagnoses, unaffected family members, and community controls. Concentrations of metabolites were analyzed and expressed as ratios. NAA/Cho, NAA/(P)Cr and Glx containing compounds showed a negative correlation with age in the frontal lobe. After covarying for age, subjects with schizophrenia had a significant reduction in the left frontal lobe NAA/Cho ratio compared with unaffected family members (P = 0.018) as well as with community non-familial (P = 0.037) controls. These MRS observations support the hypothesis of a disease-related neuronal deficit in the frontal lobe of schizophrenic patients, and relatively normal basal ganglia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.