Activation of PI3K/Akt signaling and hormone resistance in breast cancer.
Activation of PI3K/Akt signaling and hormone resistance in breast cancer.
复制标题
DOI：
10.2325/jbcs.13.137
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Maehara, Yoshihiko
中科院分区：
文献类型：
--
作者：
Tokunaga, Eriko;Kimura, Yasue;Maehara, Yoshihiko
Akt是一种丝氨酸/苏氨酸激酶，已经证明当细胞暴露于不同的凋亡刺激时，其在存活中起重要作用。近年来的研究表明，乳腺癌中Akt的异常激活与预后不良、内分泌治疗和化疗耐药有关。Akt信号通路目前作为有效治疗策略的新靶点吸引了相当大的关注。我们研究了252例原发性乳腺癌中Akt激活的发生率以及Akt激活、HER 2过表达、激素受体表达和PTEN基因改变之间的关系。pAkt阳性表达84例（33.3%）。pAkt与HER 2过表达显著相关（p
Akt is a serine/threonine kinase that has been demonstrated to play an important role in survival when cells are exposed to different apoptotic stimuli. Recent studies show that aberrant activation of Akt in breast carcinoma is associated with a poor prognosis and resistance to endocrine therapy and chemotherapy. The Akt signaling pathway is currently attracting considerable attention as a new target for effective therapeutic strategies. We investigated the incidence of Akt activation in 252 primary breast carcinomas and relationships among the activation of Akt, HER2 overexpression, hormone receptor expression, and alteration of the PTEN gene. Eighty-four cases (33.3%) were positive for pAkt expression. pAkt was significantly associated with HER2 overexpression (p