Comparison of the 2021 and 2009 Chronic Kidney Disease Epidemiology Collaboration Creatinine equation for estimated glomerular filtration rate in a Chinese population.
Comparison of the 2021 and 2009 Chronic Kidney Disease Epidemiology Collaboration Creatinine equation for estimated glomerular filtration rate in a Chinese population.
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DOI：
10.1016/j.clinbiochem.2023.03.011
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发表时间：
2023-03
影响因子：
2.8
通讯作者：
Yifeng Shen;Hao Wu;Xiaowen Liu;Jing Zhu;Wenqi Shao;Beili Wang;Bai-shen Pan;Wei Guo
中科院分区：
文献类型：
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作者：
Yifeng Shen;Hao Wu;Xiaowen Liu;Jing Zhu;Wenqi Shao;Beili Wang;Bai-shen Pan;Wei Guo
目的回顾性比较新发布的2021年和2009年慢性肾脏病流行病学协作组（CKD-EPI）方程在具有广泛临床特征的中国人群中基于肌酐估计的肾小球滤过率（eGFRcr）的临床效果。使用历史数据。设计和方法7月1日至7月1日期间在复旦大学附属中山医院就诊的患者和健康个体2020年和2022年7月1日，入组。排除标准为年龄< 18岁、截肢者、孕妇、肌肉相关疾病患者和接受过超滤或透析的患者。最终研究人群包括1，051，827例患者，中位年龄为57岁; 57.24%的入组个体为男性。使用2009年和2021年CKD-EPI方程和初始肌酐水平计算eGFRcr。结果进行了统计学评估的性别，年龄，肌酐水平，和CKD stage.ResultsThe 2021方程增加了eGFRcr在所有参与者相比，2009年方程的4.46%。与2009年CKD-EPI方程相比，2021年CKD-EPI方程的中位eGFRcr偏差为4 ml/min/1.73 m2。903，443例（85.89%）受试者因使用2021 CKD-EPI方程而导致eGFRcr升高，未导致CKD分期改变。共有11.57%的受试者（121，666例）使用2021 CKD-EPI方程改善了CKD分期。1.79%（18，817）的CKD分期与两个方程相同，0.75%（7，901）的eGFRcr较低，但与2021方程相比CKD分期无变化。应用新方程可能会导致一些患者的CKD分期发生变化，医生应该考虑这一点。
ObjectivesTo retrospectively compare the clinical effects of the newly released 2021 and 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations for estimated glomerular filtration rate based on creatinine (eGFRcr) in a Chinese population with a broad spectrum of clinical characteristics using historical data.Design and methodsPatients and healthy individuals who visited the Zhongshan Hospital, Fudan University, between July 1, 2020, and July 1, 2022, were enrolled. The exclusion criteria were age < 18 years, amputees, pregnant women, patients with muscle-related diseases, and patients who had undergone ultrafiltration or dialysis. The final study population included 1,051,827 patients with a median age of 57 years; 57.24% of the enrolled individuals were men. eGFRcr was calculated using the 2009 and 2021 CKD-EPI equations and initial creatinine level. Results were evaluated statistically by sex, age, creatinine level, and CKD stage.ResultsThe 2021 equation increased the eGFRcr in all participants compared to the 2009 equation by 4.46%. The median eGFRcr deviation of the 2021 CKD-EPI equation compared to the 2009 CKD-EPI equation was 4 ml/min/1.73 m2. 903,443 subjects (85.89%) had higher eGFRcr owing to the utilization of the 2021 CKD-EPI equation, which did not cause CKD stage change. A total of 11.57% of subjects (121,666) had improved CKD stage with the 2021 CKD-EPI equation. 1.79% (18,817) had the same CKD stage with both equations, and 0.75% (7,901) had lower eGFRcr but no change in the CKD stage with the 2021 equation.ConclusionsThe 2021 CKD-EPI equation typically produces higher eGFRcr results than the 2009 version. Applying the new equation could lead to changes in the CKD stage for some patients, which doctors should consider.