PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges.
PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges.
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DOI：
10.1016/j.mce.2016.07.005
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发表时间：
2016-12-15
影响因子：
4.1
通讯作者：
Elias, Lucila L. K.
中科院分区：
文献类型：
--
作者：
Borges, Beatriz C.;Elias, Carol F.;Elias, Lucila L. K.
能量平衡在下丘脑中是食物摄入和能量消耗整合的核心组成部分。越来越多的证据表明，能量稳态在很大程度上受到炎症挑战的影响。严重营养不良引起的炎症反应加剧可能导致恶病质。另一方面，长期的低度炎症，如在肥胖和代谢综合征中观察到的炎症，增加了患糖尿病和心脏病的风险。循环胰岛素和细胞因子如瘦素、白细胞介素和肿瘤坏死因子的变化，以及它们在下丘脑中作用的变化驱动炎症期间食物消耗的抑制。与这些反应相关的分子途径才刚刚开始解开。一个潜在的候选者是PI3K信号传导，它是控制食物摄入的不同下丘脑神经元的重要参与者。本研究综述了PI3K在炎症过程中下丘脑摄食调节中对细胞因子和胰岛素信号的作用。
Energy balance has in the hypothalamus a central component of integration of food intake and energy expenditure. An accumulating body of evidence indicates that energy homeostasis is largely affected by inflammatory challenges. Severe undernutrition caused by exacerbated inflammatory response may lead to cachexia. On the other hand, prolonged low-grade inflammation such as that observed in obesity and metabolic syndrome, raises the risk for the development of diabetes and heart diseases. Changes in circulating insulin and cytokines such as leptin, interleukins and tumor necrosis factor, as well as changes in their action in the hypothalamus drive the inhibition of food consumption during inflammation. The molecular pathways associated with these responses have only started to be unraveled. One potential candidate is the PI3K signaling, an important player in distinct hypothalamic neurons that control food intake. This study presents an overview of the current knowledge about PI3K role on cytokines and insulin signaling in the hypothalamic regulation of feeding during inflammation.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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