8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
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DOI：
10.1073/pnas.0910668107
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发表时间：
2010-05-25
影响因子：
11.1
通讯作者：
Freedman, Matthew L.
中科院分区：
文献类型：
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作者：
Ahmadiyeh, Nasim;Pomerantz, Mark M.;Freedman, Matthew L.
8q24基因沙漠包含多种上皮癌的风险位点，包括结肠癌、乳腺癌和前列腺癌。最近的证据表明，这些风险位点含有增强子。在这项研究中，数据显示，每个风险基因座带有与增强子元件一致的表观遗传标记，并与位于端粒数百个端粒酶的MYC原癌基因形成长距离染色质环，并且这些相互作用是组织特异性的。因此，我们认为8q24风险位点通过一种共同的机制作为MYC的组织特异性增强子发挥作用。
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.