The associations between knowledge, CA125 preoccupation, and distress in women with epithelial ovarian cancer
The associations between knowledge, CA125 preoccupation, and distress in women with epithelial ovarian cancer
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DOI：
10.1016/j.ygyno.2005.08.057
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发表时间：
2006-03-01
影响因子：
4.7
通讯作者：
Cohen, L
中科院分区：
文献类型：
--
作者：
Parker, PA;Kudelka, A;Cohen, L
Objective.目前研究的目的是确定卵巢癌患者对癌症和CA125检测的了解程度，以及女性对CA125水平的关注程度。我们还研究了知识和CA125关注的两个措施的痛苦（抑郁症状和焦虑）的直接和调节作用。参与者是126名患有上皮性卵巢癌的女性。在第一轮化疗或新一轮化疗开始时，对患者进行相关知识、CA125关注度和痛苦程度的问卷调查。对CA125水平的了解和关注都与抑郁和焦虑症状有关。更重要的是，知识似乎缓和了CA125职业与抑郁症状之间的关联。也就是说，对于知识水平较低的患者，更多的CA125关注与更多的抑郁症状相关。然而，在知识水平较高的女性中没有这种关联。我们的研究结果表明，通过提高对疾病和监测过程的了解，有可能减少过度关注或担心其CA125水平的女性的抑郁症状。(C)2005年爱思唯尔公司All rights reserved.
Objective. The goal of the current study was to determine how much women with ovarian cancer know about their cancer and CA125 testing and how much women focus on or are preoccupied with their CA125 levels. We also examined the direct and moderating effects of knowledge and CA125 preoccupation on two measures of distress (depressive symptoms and anxiety).Methods. Participants were 126 women with epithelial ovarian cancer. Patients completed questionnaires of knowledge, CA125 preoccupation, and distress at the beginning of the first or a new round of chemotherapy.Results. Both knowledge and preoccupation with CA125 levels were associated with depressive and anxiety symptoms. More importantly, knowledge appeared to moderate the association between CA125 preoccupation and depressive symptoms. That is, for patients with lower levels of knowledge, more CA125 preoccupation was associated with more depressive symptoms. However, there was no such association in women with higher levels of knowledge.Conclusion. Our results suggest that it may be possible to decrease depressive symptoms in women who are overly preoccupied or worried about their CA125 levels by improving their knowledge of aspects of their disease and the surveillance process. (C) 2005 Elsevier Inc. All rights reserved.