Enantioselective Aza-Henry reaction catalyzed by a bifunctional organocatalyst
Enantioselective Aza-Henry reaction catalyzed by a bifunctional organocatalyst
复制标题
DOI：
10.1021/ol0364531
复制
发表时间：
2004-02-19
期刊：
影响因子：
5.2
通讯作者：
Takemoto, Y
中科院分区：
文献类型：
--
作者：
Okino, T;Nakamura, S;Takemoto, Y
用带N，N-二甲氨基基团的手性硫脲促进亚胺与硝基烷烃的氮杂-亨利反应，得到对映选择性好的-硝基胺。研究了各种n保护亚胺作为底物。n -膦酰亚胺在化学收率和对映体选择性方面表现最好（收率高达91%，ee高达76%）。
The aza-Henry reaction of imines with nitroalkanes was promoted by chiral thiourea with an N,N-dimethylamino group to give beta-nitroamines with good enantioselectivity. Various N-protected imines were examined as substrates. N-Phosphinoylimine gave the best result in terms of chemical yield and enantioselectivity (up to 91% yield, up to 76% ee).