Direct Synthesis of 1,4-Diols from Alkenes by Iron-Catalyzed Aerobic Hydration and C-H Hydroxylation
Direct Synthesis of 1,4-Diols from Alkenes by Iron-Catalyzed Aerobic Hydration and C-H Hydroxylation
复制标题
DOI：
10.1002/anie.201308675
复制
发表时间：
2014-03-03
影响因子：
16.6
通讯作者：
Taniguchi, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Hashimoto, Takuma;Hirose, Daisuke;Taniguchi, Tsuyoshi
通过铁催化的有氧水合，可以很容易地从烯烃得到各种 1,4-二醇。该反应体系由用户友好的铁酞菁络合物、硼氢化钠和分子氧组成。此外，还检查了模型反应中额外配体对铁络合物的影响。第二个羟基是通过直接C(sp(3))H氧化作用安装的，该氧化作用基于通过烯烃的形式水合形成的瞬时烷氧基的[1,5]氢转移过程。
Various 1,4-diols are easily accessible from alkenes through iron-catalyzed aerobic hydration. The reaction system consists of a user-friendly iron phthalocyanine complex, sodium borohydride, and molecular oxygen. Furthermore, the effect of additional ligands on the iron complex was examined for a model reaction. The second hydroxy group is installed by direct C(sp(3))H oxygenation, which is based on a [1,5]hydrogen shift process of a transient alkoxy radical that is formed by formal hydration of the olefin.