Brain Network Activation as a Novel Biomarker for the Return-to-Play Pathway Following Sport-Related Brain Injury.
Brain Network Activation as a Novel Biomarker for the Return-to-Play Pathway Following Sport-Related Brain Injury.
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DOI：
10.3389/fneur.2015.00243
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发表时间：
2015
影响因子：
3.4
通讯作者：
Myer GD
中科院分区：
文献类型：
--
作者：
Kiefer AW;Barber Foss K;Reches A;Gadd B;Gordon M;Rushford K;Laufer I;Weiss M;Myer GD
儿童和青少年运动员患脑震荡的风险比成人高，恢复时间也更长，相关症状也会增加。最近也有研究表明，多次看似轻微的脑震荡可能导致神经功能缺损加重和延长。需要客观的评估和重返赛场的标准，以降低这些人群中与脑震荡事件相关的风险和发病率。最近的研究推动了脑电图作为脑损伤客观测量方法的研究。在本案例研究中，我们提出了一种新的方法，通过脑网络激活（BNA）分析作为脑震荡和恢复的生物标志物来检查事件相关电位。具体而言，通过这种方法索引的BNA评分的变化提供了神经健康的潜在指标，因为BNA评估定性和定量地索引了与脑损伤相关的网络动态。客观的工具，如这些支持准确和有效的评估脑损伤，并可能提供一个有用的步骤，在分类的时间和空间变化的脑活动后，脑震荡的打击，以及功能连接的脑网络，与脑震荡。
Children and adolescent athletes are at a higher risk for concussion than adults, and also experience longer recovery times and increased associated symptoms. It has also recently been demonstrated that multiple, seemingly mild concussions may result in exacerbated and prolonged neurological deficits. Objective assessments and return-to-play criteria are needed to reduce risk and morbidity associated with concussive events in these populations. Recent research has pushed to study the use of electroencephalography as an objective measure of brain injury. In the present case study, we present a novel approach that examines event-related potentials via a brain network activation (BNA) analysis as a biomarker of concussion and recovery. Specifically, changes in BNA scores, as indexed through this approach, offer a potential indicator of neurological health as the BNA assessment qualitatively and quantitatively indexes the network dynamics associated with brain injury. Objective tools, such as these support accurate and efficient assessment of brain injury and may offer a useful step in categorizing the temporal and spatial changes in brain activity following concussive blows, as well as the functional connectivity of brain networks, associated with concussion.