Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women
Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women
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DOI：
10.1007/s00774-022-01343-5
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发表时间：
2022-06-13
影响因子：
3.3
通讯作者：
Shiraki，Masataka
中科院分区：
文献类型：
--
作者：
Taguchi，Akira;Saito，Mitsuru;Shiraki，Masataka
引言关于口腔中诱导组织蛋白变性的物质是否与绝经后妇女的牙齿数量有关，人们知之甚少。我们试图调查日本绝经后女性的尿戊糖苷和血清同型半胱氨酸水平与牙齿数量和随后的牙齿脱落之间的关系。材料和方法在长野队列研究的参与者中，有 785 名绝经后女性（平均年龄 68.1 岁）参与了本研究。随访时对 610 名女性的牙齿数量进行了重新计数。泊松回归分析用于研究戊糖苷或同型半胱氨酸四分位数之间牙齿数量的差异，调整与牙齿数量相关的协变量。使用 Cox 比例风险模型来评估随后的牙齿脱落与戊糖素或同型半胱氨酸水平的关联。结果戊糖素四分位数与基线时的牙齿数量无关。同型半胱氨酸最高四分位数的参与者在基线时的牙齿明显少于第三和最低四分位数的参与者（两者均 p < 0.001）。第二个四分位数的牙齿比第三个四分位数 (p= 0.001) 和最低四分位数 (p< 0.001) 的牙齿少。随访期间牙齿脱落风险的增加与较高的尿戊糖苷显着相关（对于 10 pmol/mgCre，风险比 = 1.073；p= 0.001）。结论 同型半胱氨酸水平较高的绝经后女性在基线时牙齿较少。较高的戊糖素浓度会增加随后牙齿脱落的风险。高戊糖苷或同型半胱氨酸浓度可能与绝经后妇女的牙齿脱落有关。
IntroductionLittle is known about whether substances inducing tissue protein degeneration in the oral cavity are associated with the number of teeth present in postmenopausal women. We sought to investigate the association of urinary pentosidine and serum homocysteine levels with the number of teeth and subsequent tooth loss in Japanese postmenopausal women.Materials and methodsAmong participants in the Nagano Cohort Study, 785 postmenopausal women (mean age, 68.1 years) participated in the present study. The number of teeth was re-counted at the time of follow-up in 610 women. Poisson regression analysis was used to investigate differences in the number of teeth among quartiles of pentosidine or homocysteine, adjusting for covariates that correlated with the number of teeth. A Cox proportional hazard model was used to evaluate the association of subsequent tooth loss with pentosidine or homocysteine levels.ResultsPentosidine quartiles were not associated with the number of teeth at baseline. Participants in the highest homocysteine quartile had significantly fewer teeth at baseline than those in the third and lowest quartiles (p< 0.001 for both). Those in the second quartile had fewer teeth than those in the third (p= 0.001) and lowest (p< 0.001) quartiles. An increased risk of tooth loss during follow-up was significantly associated with higher urinary pentosidine (hazard ratio = 1.073 for 10 pmol/mgCre;p= 0.001).ConclusionPostmenopausal women with higher homocysteine levels had fewer teeth at baseline. A higher pentosidine concentration increased the risk of subsequent tooth loss. High pentosidine or homocysteine concentrations may be associated with tooth loss in postmenopausal women.