LOCOMOTOR HYPERACTIVITY IN NEONATAL RATS FOLLOWING ELECTROLYTIC LESIONS OF MESOCORTICAL DOPAMINE NEURONS
LOCOMOTOR HYPERACTIVITY IN NEONATAL RATS FOLLOWING ELECTROLYTIC LESIONS OF MESOCORTICAL DOPAMINE NEURONS
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DOI：
10.1016/0165-3806(83)90105-0
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
SEIDEN, LS
中科院分区：
文献类型：
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作者：
HEFFNER, TG;HELLER, A;SEIDEN, LS
在新生大鼠中研究了破坏中皮层或黑质纹状体多巴胺（DA）神经元投射的脑损伤对运动活动的影响。在4日龄大鼠的内侧腹侧被盖区的电解质损伤减少了DA含量的额叶皮层和隔膜内的42-57%，并导致2倍的增加，在运动活动在第22-24天的生活。在4日龄大鼠的黑质双侧电解损伤减少了68%的DA含量的尾壳核内，但未能改变运动活动在第22-24天的生活。显然，损失的mesocortical DA神经元的运动功能亢进的基础上看到脑DA耗竭6-羟基多巴胺注射新生大鼠，这些mesocortical DA神经元可能会影响个体发育的运动在大鼠。
The effects on locomotor activity of brain lesions that destroyed either mesocortical or nigrostriatal dopamine (DA) neuronal projections were examined in neonatal rats. Electrolytic lesions of the medial ventral tegmental area in 4-day-old rats reduced the DA content within the frontal cortex and septum by 42-57% and resulted in a 2-fold increase in locomotor activity during days 22-24 of life. Bilateral electrolytic lesions of the substantia nigra in 4-day-old rats reduced the content of DA within the caudate putamen by 68% but failed to alter locomotor activity during days 22-24 of life. Apparently, loss of mesocortical DA neurons underlies the locomotor hyperactivity seen following brain DA-depleting 6-hydroxydopamine injections in neonatal rats; these mesocortical DA neurons may normally influence the ontogeny of locomotion in the rat.