Social reward monitoring and valuation in the macaque brain
Social reward monitoring and valuation in the macaque brain
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DOI：
10.1038/s41593-018-0229-7
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发表时间：
2018-10-01
影响因子：
25
通讯作者：
Isoda, Masaki
中科院分区：
文献类型：
--
作者：
Noritake, Atsushi;Ninomiya, Taihei;Isoda, Masaki
行为受到对自己和他人的奖励的影响，但在社交环境中监控和评估奖励的神经元和神经连接尚不清楚。为了解决这个问题，我们设计了一种针对成对猴子的社会巴甫洛夫条件反射程序。尽管在数量和概率上是恒定的，但以舔和选择行为为指标的即将到来的自我奖励的主观价值随着伴侣奖励概率的增加而减少。当同种伙伴被物理物体取代时，这种价值调节是不存在的。内侧前额叶皮质神经元选择性地监控自我奖赏和伴侣奖赏信息，而中脑多巴胺能神经元将这些信息整合为主观价值。局部场电位的记录显示，内侧前额叶皮质对奖赏预测刺激的反应先于多巴胺能中脑核团，神经信息主要沿内侧前额叶皮质到中脑的方向流动。这些发现勾勒出了一条在社会环境中进行主观奖励评估的专用路径。
Behaviors are influenced by rewards to both oneself and others, but the neurons and neural connections that monitor and evaluate rewards in social contexts are unknown. To address this issue, we devised a social Pavlovian conditioning procedure for pairs of monkeys. Despite being constant in amount and probability, the subjective value of forthcoming self-rewards, as indexed by licking and choice behaviors, decreased as partner-reward probability increased. This value modulation was absent when the conspecific partner was replaced by a physical object. Medial prefrontal cortex neurons selectively monitored self-reward and partner-reward information, whereas midbrain dopaminergic neurons integrated this information into a subjective value. Recordings of local field potentials revealed that responses to reward-predictive stimuli in medial prefrontal cortex started before those in dopaminergic midbrain nuclei and that neural information flowed predominantly in a medial prefrontal cortex-to-midbrain direction. These findings delineate a dedicated pathway for subjective reward evaluation in social environments.