Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1161/jaha.116.003954
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发表时间：
2016-10-20
影响因子：
5.4
通讯作者：
Nasir K
中科院分区：
文献类型：
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作者：
Ogunmoroti O;Allen NB;Cushman M;Michos ED;Rundek T;Rana JS;Blankstein R;Blumenthal RS;Blaha MJ;Veledar E;Nasir K
美国心脏协会（American Heart Association）推出了Life's Simple 7（LS 7）指标，以评估和促进心血管健康。我们研究了LS 7指标与非心血管疾病之间的关联。我们研究了6506名年龄在45至84岁之间的男性和女性，他们参加了多种族动脉粥样硬化研究。中位随访时间为10.2年。LS 7指标的每个组成部分（吸烟、体重指数、体力活动、饮食、总胆固醇、血压和血糖）都被分配了分数，0表示“差”类别; 1表示“中等”，2表示“理想”。LS 7评分范围为0 - 14，根据这些分数创建，并分类为最佳（11-14）、平均（9-10）和不足（0-8）。根据国际疾病分类第9次修订版的自我报告住院情况、癌症、慢性肾病、肺炎、深静脉血栓栓塞/肺栓塞、慢性阻塞性肺病、痴呆和髋部骨折的诊断，计算结局的风险比和每1000人年的事件发生率。对年龄、性别、种族/民族、收入和教育进行了调整。总体而言，非心血管疾病事件发生率随着LS 7评分的增加而降低。以不适当的LS 7评分作为参考，最佳评分与非心血管疾病事件风险降低相关。癌症的风险比为0.80（0.64-0.98）;慢性肾脏疾病为0.38（0.27-0.54）;肺炎为0.57（0.40-0.80）;深静脉血栓栓塞/肺栓塞为0.52（0.33-0.82）;慢性阻塞性肺疾病为0.51（0.31-0.83）。美国心脏协会的LS 7评分确定了易受多种慢性非血管性疾病影响的个体。这些结果表明，改善心血管健康也将减少癌症和其他慢性疾病的负担。
The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We examined the association between the LS7 metrics and noncardiovascular disease. We studied 6506 men and women aged between 45 and 84 years, enrolled in the Multi‐Ethnic Study of Atherosclerosis. Median follow‐up time was 10.2 years. Each component of the LS7 metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and blood glucose) was assigned points, 0 indicates “poor” category; 1, “intermediate,” and 2, “ideal.” The LS7 score, ranged from 0 to 14, was created from the points and categorized as optimal (11–14), average (9–10), and inadequate (0–8). Hazard ratios and event rates per 1000 person‐years were calculated for outcomes based on self‐reported hospitalizations with the International Classification of Diseases, 9th Revision, diagnoses of cancer, chronic kidney disease, pneumonia, deep venous thromboembolism/pulmonary embolism, chronic obstructive pulmonary disease, dementia, and hip fracture. Analyses were adjusted for age, sex, race/ethnicity, income, and education. Overall, noncardiovascular disease event rates were lower with increasing LS7 scores. With the inadequate LS7 score as reference, an optimal score was associated with a decreased risk for noncardiovascular disease events. The hazard ratio for cancer was, 0.80 (0.64–0.98); chronic kidney disease, 0.38 (0.27–0.54); pneumonia, 0.57 (0.40–0.80); deep venous thromboembolism/pulmonary embolism, 0.52 (0.33–0.82), and chronic obstructive pulmonary disease, 0.51 (0.31–0.83). The American Heart Association's LS7 score identified individuals who were vulnerable to multiple chronic nonvascular conditions. These results suggest that improving cardiovascular health will also reduce the burden of cancer and other chronic diseases.