Asteriscane-Type Sesquiterpenoids from the Soft Coral Sinularia capillosa
Asteriscane-Type Sesquiterpenoids from the Soft Coral Sinularia capillosa
复制标题
DOI：
10.1021/np400480p
复制
发表时间：
2013-09-01
影响因子：
5.1
通讯作者：
Lin, Wenhan
中科院分区：
文献类型：
--
作者：
Chen, Dawei;Chen, Wei;Lin, Wenhan
对南海软珊瑚Sinularia capillosa进行化学鉴定，分离出14个新的星形类倍半萜类化合物，分别为capillosananes A- n（1-14）、4个新的seco-asteriscanes、capillosananes O-R（15-18）、(-)-sinularone A和sinularone A。通过广泛的光谱分析确定了它们的结构，通过CD和ECD计算、Mosher法和化学转化确定了它们的绝对构型。这是软珊瑚中首次报道的星链型倍半萜类化合物，其中capillosananes Q（17）和R（18）代表了新的次星链骨架。Capillosanane A对Balanus amphiitrite表现出较强的抗污染活性，IC50值为9.70 μ M，而Capillosanane B、I和(-)-sinularone A在体外抑制炎症相关的tnf - α。
Chemical examination of the soft coral Sinularia capillosa collected from the South China Sea resulted in the isolation of 14 new asteriscane-type sesquiterpenoids, namely, capillosananes A-N (1-14), four new seco-asteriscanes, capillosananes O-R (15-18), and (-)-sinularone A and sinularone A. Their structures were determined on the basis of extensive spectroscopic analyses, while the absolute configurations were determined by CD and ECD calculation, Mosher's method, and chemical conversion. This is the first report of asteriscane-type sesquiterpenoids from soft corals, and capillosananes Q(17) and R (18) represent new seco-asteriscane skeletons. Capillosanane A exhibited potent antifouling activity against Balanus amphitrite, with an IC50 value of 9.70 mu M, while capillosananes B and I and (-)-sinularone A inhibited inflammation-related TNF-alpha in vitro.