Cefiderocol Resistance in Acinetobacter baumannii: Roles of β-Lactamases, Siderophore Receptors, and Penicillin Binding Protein 3
Cefiderocol Resistance in Acinetobacter baumannii: Roles of β-Lactamases, Siderophore Receptors, and Penicillin Binding Protein 3
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DOI：
10.1128/aac.01221-20
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发表时间：
2020-11-01
影响因子：
4.9
通讯作者：
Quale, John
中科院分区：
文献类型：
--
作者：
Malik, Saquib;Kaminski, Monica;Quale, John
Cefiderocol是一种铁载体头孢菌素，对许多多重耐药（MDR）革兰氏阴性病原体具有活性。我们研究了12株鲍曼不动杆菌的耐药机制，头孢地罗可MIC范围为32 μ g/ml。β-内酰胺酶活性无法解释头孢地罗克耐药性。头孢地罗可耐药与铁载体受体基因pirA的表达减少有关。涉及PBP 3的突变可能导致了一种菌株的耐药性。需要进一步的研究来评估其他铁载体受体的作用。
Cefiderocol is a siderophore cephalosporin active against many multidrugresistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from 32 mu g/ml. Cefiderocol resistance could not be explained by beta-lactamase activity. Cefiderocol resistance was associated with reduced expression of the siderophore receptor gene pirA. Mutations involving PBP3 may have contributed to resistance in one strain. Additional studies are needed to assess the role of other siderophore receptors.