Neuropeptide-Y. A peptide found in human coronary arteries constricts primarily small coronary arteries to produce myocardial ischemia in dogs.
Neuropeptide-Y. A peptide found in human coronary arteries constricts primarily small coronary arteries to produce myocardial ischemia in dogs.
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DOI：
10.1172/jci114004
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发表时间：
1989-04
期刊：
影响因子：
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通讯作者：
M. F. Maturi;R. Greene;E. Speir;C. Burrus;L. Dorsey;D. Markle;M. Maxwell;W. Schmidt;S. Goldstein;R. Patterson
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文献类型：
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作者：
M. F. Maturi;R. Greene;E. Speir;C. Burrus;L. Dorsey;D. Markle;M. Maxwell;W. Schmidt;S. Goldstein;R. Patterson
神经肽- y （NPY）是一种脑肽，位于人类冠状动脉的壁中。本研究评估了NPY对40只氯氯麻醉开胸犬冠状动脉循环的影响。冠状动脉内NPY （42 nmol / 5.2 min）在不改变心率或主动脉压的情况下导致冠状动脉血流量减少39%。为了确定这种血管收缩是否会引起缺血，我们测量了7只狗（I组）的心肌内pH值，结果显示NPY后心内膜下pH值从7.45 +/- 0.06降至7.37 +/- 0.06 (P < 0.0002)，灌注区心内膜下pH值从7.45 +/- 0.06降至7.40 +/- 0.05 （P < 0.04）。放射性核素血管造影测量的左室射血分数（LVEF）在NPY期间从0.52 +/- 0.08 U降至0.42 +/- 0.12 U （n = 5, P < 0.01）。在其他9只动物（V组）中，8只动物npy诱导的血管收缩也与心电图（ECG）上的ST-T波变化有关。在另一组6只狗（IV组）中，小血管阻力的变化占总阻力增加的94%，因此NPY的主要血管收缩作用是在小冠状动脉上发挥的。因此，在人类冠状动脉中发现的肽NPY引起主要是小冠状动脉的收缩，其严重程度足以产生心肌缺血（ECG ST-T波变化），并降低狗的心肌内pH和LVEF。
Neuropeptide-Y (NPY), a brain peptide, is located in the walls of human coronary arteries. This study assessed the effects of NPY on the coronary circulation in 40 chloralose-anesthetized, open-chest dogs. Intracoronary NPY (42 nmol over 5.2 min) caused a 39% reduction in coronary blood flow without changing heart rate or aortic pressure. To determine whether this vasoconstriction could produce ischemia, intramyocardial pH was measured in seven dogs (group I) and decreased from 7.45 +/- 0.06 to 7.37 +/- 0.06 pH units after NPY in the subendocardium (P less than 0.0002), and from 7.45 +/- 0.06 to 7.40 +/- 0.05 pH units (P less than 0.04) in the subepicardium of the infused zone. Left ventricular ejection fraction (LVEF), measured by radionuclide angiography, decreased from 0.52 +/- 0.08 to 0.42 +/- 0.12 U (n = 5, P less than 0.01) during NPY. NPY-induced vasoconstriction was also associated with ST-T wave changes on the electrocardiogram (ECG) in eight of nine other animals (group V). In another group of six dogs (group IV), the change in small vessel resistance accounted for 94% of the increase in total resistance, so that the primary vasoconstrictor effect of NPY was exerted on small coronary arteries. Thus, NPY, a peptide found in human coronary arteries, caused constriction of primarily small coronary arteries that was severe enough to produce myocardial ischemia as determined by ECG ST-T wave changes, and decreases in intramyocardial pH and LVEF in dogs.