The lack of long-range negative correlations in glucose dynamics is associated with worse glucose control in patients with diabetes mellitus
The lack of long-range negative correlations in glucose dynamics is associated with worse glucose control in patients with diabetes mellitus
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DOI：
10.1016/j.metabol.2011.12.007
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发表时间：
2012-07-01
影响因子：
9.8
通讯作者：
Yamamoto, Yoshiharu
中科院分区：
文献类型：
--
作者：
Ogata, Hitomi;Tokuyama, Kumpei;Yamamoto, Yoshiharu
在非卧床环境中测量的血糖动态是流动的，表现出相当的复杂性。我们最近发现，在糖尿病患者中，被认为反映血糖在相当长一段时间内可控的血糖动力学的长期负相关性是不存在的。这一点通过去趋势波动分析(DFA)得到了证实，DFA是一种用于检测长期相关性的改进的随机游走分析方法。在这项研究中，我们进一步评估了104名日本糖尿病患者的糖化或胰岛素控制血红蛋白A(1c)(HBA(1c))、糖化白蛋白(GA)、1，5-脱水葡萄糖醇和尿C肽免疫反应性的临床指标与最近提出的基于DFA的血糖持续监测指标之间的关系。(1)HbA(1c)与长期标度指数α(2)(r=0.236，P<；0.05)，(2)GA和α(2)(r=0.254，P<；0.05)，(3)GA与短期标度指数α(1)(r=0.233，P<；0.05)，以及(4)尿C肽免疫反应性与平均血糖波动(r=-0.294，P<；.01)。因此，我们得出结论，长期DFA标度指数的增加表明血糖动力学中缺乏长期负相关性，反映了临床上使用HBA(1c)和GA参数确定的平均血糖控制的异常。(C)2012 Elsevier Inc.保留所有权利。
Glucose dynamics measured in ambulatory settings are fluid in nature and exhibit substantial complexity. We recently showed that a long-range negative correlation of glucose dynamics, which is considered to reflect blood glucose controllability over a substantial period, is absent in patients with diabetes mellitus. This was demonstrated using detrended fluctuation analysis (DFA), a modified random-walk analysis method for the detection of long-range correlations. In the present study, we further assessed the relationships between the established clinical indices of glycemic or insulinogenic control of hemoglobin A(1c) (HbA(1c)), glycated albumin (GA), 1,5-anhydroglucitol, and urine C-peptide immunoreactivity and the recently proposed DFA-based indices obtained from continuous glucose monitoring in 104 Japanese diabetic patients. Significant correlations between the following parameters were observed: (1) HbA(1c) and the long-range scaling exponent alpha(2) (r = 0.236, P < .05), (2) GA and alpha(2) (r = 0.254, P < .05), (3) GA and the short-range scaling exponent alpha(1) (r = 0.233, P < .05), and (4) urine C-peptide immunoreactivity and the mean glucose fluctuations (r = -0.294, P < .01). Therefore, we concluded that increases in the long-range DFA scaling exponent, which are indicative of the lack of a long-range negative correlation in glucose dynamics, reflected abnormalities in average glycemic control as clinically determined using HbA(1c), and GA parameters. (c) 2012 Elsevier Inc. All rights reserved.