Intrinsic functional architecture in the anaesthetized monkey brain
Intrinsic functional architecture in the anaesthetized monkey brain
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DOI：
10.1038/nature05758
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发表时间：
2007-05-03
期刊：
影响因子：
64.8
通讯作者：
Raichle, M. E.
中科院分区：
文献类型：
--
作者：
Vincent, J. L.;Patel, G. H.;Raichle, M. E.
研究大脑功能的传统方法是测量对受控感觉、运动和认知范式的生理反应。然而，大脑的大部分能量消耗都用于正在进行的代谢活动，而这些活动与任何特定的刺激或行为没有明显的联系（1）。旨在了解这种持续活动的人体功能性磁共振成像研究表明，血氧水平依赖性信号的自发波动在静息状态下连续发生。在人类中，这些波动在广泛分布的皮质系统中是时间上一致的，这些系统概括了实验性任务诱发的反应的功能结构（2-6\）。在这里，我们表明，同样的现象是存在于麻醉猴子，即使在已知的麻醉水平，诱导深刻的意识丧失。我们具体展示了三个众所周知的系统（眼动，somatomotor和视觉）和“默认”系统，一些人认为，以支持独特的人类能力的一组大脑区域内的连贯自发波动。我们的研究结果表明，连贯的系统波动可能反映了超越意识水平的大脑功能组织的进化保守方面。
The traditional approach to studying brain function is to measure physiological responses to controlled sensory, motor and cognitive paradigms. However, most of the brain's energy consumption is devoted to ongoing metabolic activity not clearly associated with any particular stimulus or behaviour(1). Functional magnetic resonance imaging studies in humans aimed at understanding this ongoing activity have shown that spontaneous fluctuations of the blood-oxygen-level-dependent signal occur continuously in the resting state. In humans, these fluctuations are temporally coherent within widely distributed cortical systems that recapitulate the functional architecture of responses evoked by experimentally administered tasks(2-6\). Here, we show that the same phenomenon is present in anaesthetized monkeys even at anaesthetic levels known to induce profound loss of consciousness. We specifically demonstrate coherent spontaneous fluctuations within three well known systems ( oculomotor, somatomotor and visual) and the 'default' system, a set of brain regions thought by some to support uniquely human capabilities. Our results indicate that coherent system fluctuations probably reflect an evolutionarily conserved aspect of brain functional organization that transcends levels of consciousness.