Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis.
Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis.
复制标题
DOI：
10.2217/bmm.15.103
复制
发表时间：
2016
影响因子：
2.2
通讯作者：
Lingxie Song;Lian Meng;Jifeng Peng;Ping Wang;S. Qi;Wanyu Li;Chunxia Liu;Feng Li
中科院分区：
文献类型：
--
作者：
Lingxie Song;Lian Meng;Jifeng Peng;Ping Wang;S. Qi;Wanyu Li;Chunxia Liu;Feng Li
目的Notch1在宫颈癌中的表达与以前的研究结果不一致和矛盾。本研究的目的是评估Notch 1与宫颈癌之间的关系。方法从不同的数据库中检索现有的研究，并使用Review Managers 5.3软件进行分析。结果共纳入798例样本。Notch 1在癌组织中的表达高于癌前组织（p = 0.0003）和正常组织（p < 0.02）。而Notch 1在胃癌和癌前病变中的表达差异无统计学意义（p = 0.35）。此外，淋巴结转移（p = 0.02）与宫颈癌中Notch 1的高表达相关。结论Notch 1的过度表达提示了细胞的攻击性生物学行为。
AIM Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer. METHODS Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis. RESULTS A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer. CONCLUSION Notch1 over-expression indicated aggressive biological behaviors.